Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4918521 | 0.89 | EBP (0.41) | LMNASIGMAR1EBPALDH1A1DHCR7 | |
| SCHEMBL2188938 | 0.84 | LMNA (0.40) | LMNASIGMAR1EBPALDH1A1MAPT | |
| SCHEMBL2188337 | 0.84 | LMNA (0.40) | LMNASIGMAR1EBPALDH1A1MAPT | |
| SCHEMBL2188331 | 0.84 | LMNA (0.40) | LMNASIGMAR1EBPALDH1A1MAPT | |
| SCHEMBL12507887 | 0.84 | SIGMAR1 (0.38) | LMNASIGMAR1EBPLTA4HL3MBTL1 | |
| SCHEMBL1713596 | 0.74 | SIGMAR1 (0.59) | HRH3SIGMAR1ALDH1A1 | |
| SCHEMBL13181162 | 0.73 | HRH3 (0.54) | HRH3CCR5SIGMAR1EBPALDH1A1 | |
| SCHEMBL12507636 | 0.73 | MCHR1 (0.38) | LMNASIGMAR1EBPALDH1A1DHCR7 | |
| SCHEMBL5769219 | 0.72 | AVPR1A (0.40) | LMNACCR5SIGMAR1EBPLTA4H | |
| SCHEMBL25358288 | 0.72 | HRH3 (0.48) | HRH3CCR5SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | SYNGENTA CROP PROTECTION LLC | 2014-01-30 | — | — | US | disclosed |
| US-8354423-B2 | Insecticidal spironindane derivatives | SYNGENTA CROP PROTECTION LLC (US) | 2013-01-15 | — | — | US | disclosed |
| EP-1697327-B1 | INSECTICIDAL SPIROINDANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-07-13 | — | — | EP | disclosed |
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | NR1D1, NR1D2, NR1I3 | HRH3 467/4885LMNA 2860/4885CCR5 1832/4885 |
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | NR1D1, NR1D2, NR1I3 | HRH3 467/4885LMNA 2860/4885CCR5 1832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.