Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.58 |
| ▸ | PPARD | Q03181 | 3/20 | 0.58 |
| ▸ | RXRA | P19793 | 3/20 | 0.57 |
| ▸ | RXRB | P28702 | 2/20 | 0.57 |
| ▸ | RXRG | P48443 | 2/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
| ▸ | MMP12 | P39900 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4217510 | 0.87 | KDM4E (0.68) | PTGS1AKR1C3AKR1C2RXRARXRB | |
| SCHEMBL4201864 | 0.85 | PTGS1 (0.58) | PTGS1AKR1C3AKR1C2PPARDCYP11B1 | |
| SCHEMBL3569849 | 0.83 | PPARD (0.56) | PPARDRXRARXRBRXRGSMN1; SMN2 | |
| SCHEMBL29087697 | 0.83 | CYP11B1 (0.80) | PTGS1AKR1C3AKR1C2PPARDRXRA | |
| SCHEMBL30646825 | 0.83 | CYP11B1 (0.80) | PTGS1AKR1C3AKR1C2PPARDRXRA | |
| SCHEMBL677776 | 0.83 | RXRA (0.58) | PTGS1AKR1C3AKR1C2PPARDRXRA | |
| SCHEMBL240822 | 0.81 | KDM4E (0.74) | PTGS1AKR1C3AKR1C2KDM4EPOLB | |
| SCHEMBL491794 | 0.80 | RXRA (0.53) | PTGS1AKR1C2PPARDRXRARXRB | |
| Hydrochloric Acid SCHEMBL2022863 | 0.80 | KDM4E (0.72) | PTGS1AKR1C3AKR1C2KDM4EPOLB | |
| Hydrogen Sulfide SCHEMBL29062416 | 0.80 | KDM4E (0.72) | PTGS1AKR1C3AKR1C2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016039-B1 | TERPHENYL DERIVATIVES FOR TREATMENT OF ALZHEIMER' S DISEASE | ORTHO MCNEIL JANSSEN PHARM (US) | 2012-08-01 | — | — | EP | claimed |
| US-8106236-B2 | Triaryl compounds and derivates thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2012-01-31 | — | — | US | claimed |
| EP-1847524-B1 | Terphenyl derivatives for treatment of Alzheimer's disease | CELLZOME LTD (GB) | 2009-10-14 | — | — | EP | claimed |
| US-20070254957-A1 | TRIARYL COMPOUNDS AND DERIVATES THEREOF | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2007-11-01 | — | — | US | claimed |
| EP-1847524-A1 | Terphenyl derivatives for treatment of Alzheimer's disease | Cellzome (UK) Ltd. (GB) | 2007-10-24 | — | — | EP | claimed |
| US-8106236-B2 | Triaryl compounds and derivates thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2012-01-31 | — | — | US | disclosed |
| EP-1847524-B1 | Terphenyl derivatives for treatment of Alzheimer's disease | CELLZOME LTD (GB) | 2009-10-14 | — | — | EP | disclosed |
| US-20070254957-A1 | TRIARYL COMPOUNDS AND DERIVATES THEREOF | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2007-11-01 | — | — | US | disclosed |
| EP-1847524-A1 | Terphenyl derivatives for treatment of Alzheimer's disease | Cellzome (UK) Ltd. (GB) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254957-A1 | TRIARYL COMPOUNDS AND DERIVATES THEREOF | BACE1, BACE2, APP | PTGS1 3643/4885AKR1C3 609/4885AKR1C2 1075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.