Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 11/20 | 0.40 |
| ▸ | CENPE | Q02224 | 1/20 | 0.39 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107051 | 0.79 | CENPE (0.47) | CHEK2CENPEPRSS12RHEBTP53 | |
| SCHEMBL5569249 | 0.78 | CENPE (0.48) | CENPES1PR1TP53MAPT | |
| SCHEMBL4717871 | 0.76 | CENPE (0.43) | CHEK2CENPEPDE4APDE4BPDE4C | |
| SCHEMBL4717868 | 0.75 | HDAC3 (0.46) | CHEK2CENPEPDE4APDE4BPDE4C | |
| SCHEMBL2617481 | 0.73 | CHEK2 (0.47) | CHEK2CENPE | |
| SCHEMBL2102868 | 0.72 | CENPE (0.47) | CENPETP53MAPT | |
| SCHEMBL13644431 | 0.71 | CENPE (0.45) | CHEK2CENPEPRSS12S1PR1RHEB | |
| SCHEMBL2103765 | 0.71 | CENPE (0.45) | CHEK2CENPEPRSS12S1PR1RHEB | |
| SCHEMBL4400479 | 0.71 | CENPE (0.45) | CHEK2CENPEPRSS12S1PR1RHEB | |
| SCHEMBL2105475 | 0.71 | CENPE (0.48) | CENPETP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |