Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 9/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2617481 | 0.88 | CHEK2 (0.47) | CENPECHEK2HDAC6HDAC3HDAC1 | |
| SCHEMBL4721152 | 0.84 | CENPE (0.52) | CENPE | |
| SCHEMBL2107051 | 0.81 | CENPE (0.47) | CENPECHEK2HDAC6HDAC3HDAC1 | |
| SCHEMBL4717868 | 0.81 | HDAC3 (0.46) | CENPECHEK2HDAC6HDAC3HDAC1 | |
| SCHEMBL2617484 | 0.79 | HPSE (0.46) | CENPECHEK2HDAC6HDAC3HDAC1 | |
| SCHEMBL4722528 | 0.78 | CENPE (0.53) | CENPEHDAC6HDAC1HDAC8 | |
| SCHEMBL4718072 | 0.77 | CENPE (0.46) | CENPE | |
| SCHEMBL4720776 | 0.77 | CENPE (0.44) | CENPE | |
| SCHEMBL4720908 | 0.77 | MEN1 (0.47) | CENPEHDAC1HDAC2 | |
| SCHEMBL4521076 | 0.77 | CENPE (0.47) | CENPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |