Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.45 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719991 | 0.81 | CENPE (0.48) | CENPES1PR1S1PR3KIFC1CSNK2A1 | |
| SCHEMBL4721152 | 0.80 | CENPE (0.52) | CENPES1PR1S1PR3KIFC1CSNK2A1 | |
| SCHEMBL4521076 | 0.79 | CENPE (0.47) | CENPES1PR1S1PR3KIFC1CSNK2A1 | |
| SCHEMBL4721149 | 0.79 | CENPE (0.55) | CENPES1PR1S1PR3KIFC1MEN1 | |
| SCHEMBL4920328 | 0.78 | CHEK2 (0.40) | CENPES1PR1TP53MAPT | |
| SCHEMBL2104964 | 0.78 | CENPE (0.53) | CENPES1PR1S1PR3KIFC1CSNK2A1 | |
| SCHEMBL2103268 | 0.76 | CENPE (0.56) | CENPES1PR1S1PR3KIFC1CSNK2A1 | |
| SCHEMBL2101902 | 0.75 | CENPE (0.51) | CENPES1PR1S1PR3KIFC1CSNK2A1 | |
| SCHEMBL2617308 | 0.74 | CENPE (0.64) | CENPES1PR1S1PR3KIFC1MEN1 | |
| SCHEMBL2617225 | 0.73 | CENPE (0.63) | CENPES1PR1S1PR3KIFC1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149516-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INCORPORATED | 2007-06-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149516-A1 | Certain chemical entities, compositions, and methods | KIF5B, KIF2C, PLK1 | CENPE 54/4885S1PR1 2943/4885S1PR3 2814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.