Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.36 |
| ▸ | SSTR2 | P30874 | 4/20 | 0.36 |
| ▸ | BACE1 | P56817 | 4/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4925336 | 0.93 | HRH4 (0.40) | HRH4ENPP1BACE1BRD4ADORA2A | |
| SCHEMBL4921370 | 0.88 | PDE5A (0.37) | HRH4ENPP1SSTR2BACE1ADORA2A | |
| SCHEMBL2661488 | 0.83 | GRM2 (0.41) | HRH4 | |
| SCHEMBL2661938 | 0.83 | GABRG2 (0.38) | HRH4ENPP1ENPP3NPC1RAB9A | |
| SCHEMBL2661220 | 0.82 | HRH4 (0.41) | HRH4ENPP1SSTR2BACE1LRRK2 | |
| SCHEMBL2656734 | 0.82 | BACE1 (0.38) | BACE1ADORA2AADORA1MAPKAPK2RAB9A | |
| SCHEMBL2660620 | 0.81 | GABRG2 (0.41) | HRH4ENPP1SSTR2MAPKAPK2 | |
| SCHEMBL2655674 | 0.81 | GABRA1 (0.46) | ADORA2ALRRK2MAPKAPK2RAB9A | |
| SCHEMBL4923143 | 0.81 | ALDH1A1 (0.39) | HRH4BACE1ADORA2AADORA1NPC1 | |
| SCHEMBL4920722 | 0.81 | KDM4E (0.43) | HRH4ENPP1BACE1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | claimed |
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | COMT, BACE1, BDNF | HRH4 167/4885ENPP1 3350/4885SSTR2 1733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.