Sugi Predict

Sugi Predict / Compounds / SCHEMBL4921071

SCHEMBL4921071

SCHEMBL4921071

COC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TTR P02766 1/20 0.61
▸ PTPRC P08575 5/20 0.59
▸ MAPT P10636 5/20 0.57
▸ NPC1 O15118 4/20 0.57
▸ RAB9A P51151 4/20 0.57
▸ LMNA P02545 2/20 0.57
▸ SMN1; SMN2 Q16637 2/20 0.57
▸ ALDH1A1 P00352 2/20 0.57
▸ S100A4 P26447 1/20 0.57
▸ ATM Q13315 1/20 0.55
▸ HTR7 P34969 1/20 0.54
▸ HTR2B P41595 1/20 0.54
▸ CDC25B P30305 2/20 0.54
▸ PTPRF P10586 1/20 0.54
▸ PTPN1 P18031 1/20 0.54
▸ PTGS2 P35354 1/20 0.54
▸ MITF O75030 1/20 0.53
▸ CASP3 P42574 1/20 0.53
▸ CDC25A P30304 1/20 0.52
▸ HTT P42858 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2265496 0.98 TTR (0.62) TTRPTPRCMAPTNPC1RAB9A
SCHEMBL26120300 0.97 S100A4 (0.62) TTRPTPRCMAPTNPC1RAB9A
SCHEMBL25260739 0.93 PTPRC (0.57) TTRPTPRCMAPTNPC1RAB9A
SCHEMBL31065274 0.93 PTPRC (0.57) TTRPTPRCMAPTNPC1RAB9A
SCHEMBL9769408 0.93 PTPRC (0.60) TTRPTPRCMAPTNPC1RAB9A
SCHEMBL9769488 0.93 PTPRC (0.60) TTRPTPRCMAPTNPC1RAB9A
SCHEMBL11846453 0.93 PTPRC (0.60) TTRPTPRCMAPTNPC1RAB9A
SCHEMBL13550874 0.89 PTPRC (0.60) TTRPTPRCMAPTNPC1RAB9A
SCHEMBL26118036 0.89 TSHR (0.57) PTPRCMAPTNPC1RAB9ALMNA
SCHEMBL28359870 0.86 TTR (0.61) TTRPTPRCMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190142798-A1 POLYMER-DES-ETHYL SUNITINIB CONJUGATES NEKTAR THERAPEUTICS 2019-05-16 — — US disclosed
US-10220020-B2 Polymer-des-ethyl sunitinib conjugates NEKTAR THERAPEUTICS (US) 2019-03-05 — — US disclosed
US-8921243-B2 Fabrics comprising a photocatalyst to produce singlet oxygen from ambient oxygen VENTANA RESEARCH CORPORATION 2014-12-30 — — US disclosed
US-8921243-B2 Fabrics comprising a photocatalyst to produce singlet oxygen from ambient oxygen VENTANA RESEARCH CORPORATION 2014-12-30 — — US disclosed
US-8481446-B2 Chemically-resistant coating composition VENTANA RESEARCH CORPORATION 2013-07-09 — — US disclosed
US-8481446-B2 Chemically-resistant coating composition VENTANA RESEARCH CORPORATION 2013-07-09 — — US disclosed
US-20120135651-A1 Fabrics Comprising a Photocatalyst to Produce Singlet Oxygen from Ambient Oxygen VENTANA RESEARCH CORPORATION 2012-05-31 — — US disclosed
US-20120135651-A1 Fabrics Comprising a Photocatalyst to Produce Singlet Oxygen from Ambient Oxygen VENTANA RESEARCH CORPORATION 2012-05-31 — — US disclosed
WO-2011142838-A2 CHEMICALLY-RESISTANT COATING COMPOSITION LOMBARID JOHN L (US) 2011-11-17 — — WO disclosed
US-20100279850-A1 CHEMICALLY-RESISTANT COATING COMPOSITION VENTANA RESEARCH CORPORATION 2010-11-04 — — US disclosed
WO-2010118180-A1 FABRICS COMPRISING A PHOTOCATALYST TO PRODUCE SINGLET OXYGEN FROM AMBIENT OXYGEN LOMBARDI JOHN L (US) 2010-10-14 — — WO disclosed
US-20080200551-A1 Flourene Derivative ASTELLAS PHARMA INC. (JP) 2008-08-21 — — US disclosed
US-20080171788-A1 Medicament For Irritable Bowel Syndrome ASTELLAS PHARMA INC. (JP) 2008-07-17 — — US disclosed
US-20080161419-A1 Prophylactic Antimigraine Agents ASTELLAS PHARMA INC. (JP) 2008-07-03 — — US disclosed
EP-1852129-A1 REMEDY FOR IRRITABLE BOWEL SYNDROME Astellas Pharma Inc. (JP) 2007-11-07 — — EP disclosed
EP-1762599-A1 Ink composition, inkjet recording method, printed material, process for producing lithographic plate, and lithographic printing plate FUJIFILM Corporation (JP) 2007-03-14 — — EP disclosed
EP-1728784-A1 FLUORENE DERIVATIVE Astellas Pharma Inc. (JP) 2006-12-06 — — EP disclosed
EP-1716867-A1 PREVENTIVES FOR MIGRAINE Astellas Pharma Inc. (JP) 2006-11-02 — — EP disclosed
CN-1842517-A Fluorene derivatives ASTELLAS PHARMA INC (JP) 2006-10-04 — — CN disclosed
US-3939276-A ANTHRAQUINONES, ASTHMA, ANTIALLERGENS BURROUGHS WELLCOME CO. (US) 1976-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10220020-B2 Polymer-des-ethyl sunitinib conjugates KDR, FLT4, FLT1 TTR 2968/4885PTPRC 794/4885MAPT 918/4885
US-20080161419-A1 Prophylactic Antimigraine Agents HTR2B, HTR7, HTR1A TTR 3579/4885PTPRC 2235/4885MAPT 3582/4885
US-20080200551-A1 Flourene Derivative HTR2B, HTR7, HTR2C TTR 4607/4885PTPRC 2610/4885MAPT 3927/4885
US-20080171788-A1 Medicament For Irritable Bowel Syndrome HTR7, HTR5A, HTR3B TTR 3872/4885PTPRC 1236/4885MAPT 4073/4885
US-20100279850-A1 CHEMICALLY-RESISTANT COATING COMPOSITION DNMT1, VCL, DNMT3L TTR 2066/4885PTPRC 1289/4885MAPT 284/4885
US-20190142798-A1 POLYMER-DES-ETHYL SUNITINIB CONJUGATES KDR, FLT4, FLT1 TTR 2968/4885PTPRC 794/4885MAPT 918/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.