Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | CMA1 | P23946 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31190634 | 0.86 | ELANE (0.48) | GSK3AGSK3BCMA1ALDH1A1MAPT | |
| SCHEMBL4921010 | 0.79 | HSD17B10 (0.44) | ALDH1A1MAPTKDM4E | |
| SCHEMBL17360667 | 0.78 | CMA1 (0.59) | GSK3AGSK3BCMA1GAAGRM2 | |
| SCHEMBL2661493 | 0.76 | CMA1 (0.52) | CMA1GAAALDH1A1MEN1KMT2A | |
| SCHEMBL2657547 | 0.74 | CA1 (0.35) | ALDH1A1MAPTPOLB | |
| SCHEMBL7260345 | 0.74 | GSK3A (0.60) | GSK3AGSK3BCMA1GAAGRM2 | |
| SCHEMBL6101068 | 0.73 | GAA (0.73) | GSK3AGSK3BCMA1GAAGRM2 | |
| SCHEMBL3659094 | 0.73 | CMA1 (0.53) | GSK3AGSK3BCMA1GAAGRM2 | |
| SCHEMBL28946779 | 0.73 | ALDH1A1 (0.52) | GSK3AGSK3BCMA1GAAGRM2 | |
| SCHEMBL11432095 | 0.72 | GAA (0.68) | GSK3AGSK3BCMA1GAAGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | COMT, BACE1, BDNF | GSK3A 82/4885GSK3B 61/4885CMA1 2821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.