Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.48 |
| ▸ | HTR3B | O95264 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | HTR3A | P46098 | 2/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4926745 | 0.99 | NPC1 (0.48) | NPC1RAB9AHRH3KDM4EALDH1A1 | |
| SCHEMBL4907107 | 0.82 | MAPT (0.48) | RAB9AKDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL4913227 | 0.80 | MAPT (0.40) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4908143 | 0.80 | HTR3E (0.48) | NPC1RAB9AKDM4EALDH1A1HTR3E | |
| Hydrochloric Acid SCHEMBL4899154 | 0.79 | MAPT (0.39) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4901792 | 0.79 | HTR3E (0.47) | NPC1RAB9AKDM4EALDH1A1HTR3E | |
| SCHEMBL4901811 | 0.76 | KDM4E (0.38) | NPC1RAB9AKDM4EALDH1A1HTR3A | |
| SCHEMBL4910047 | 0.76 | ALDH1A1 (0.46) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4908538 | 0.76 | HPGD (0.36) | NPC1RAB9AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4905049 | 0.75 | ABCB1 (0.45) | HRH3KDM4EALDH1A1TDP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119467-A1 | Purine Derivatives, Compositions Containing Them and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-05-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119467-A1 | Purine Derivatives, Compositions Containing Them and Use Thereof | TYMP, HPRT1, IMPDH1 | NPC1 1908/4885RAB9A 3384/4885HRH3 3074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.