Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ASF1A | Q9Y294 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4923704 | 1.00 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL2993484 | 0.90 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL29786246 | 0.90 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL10147915 | 0.90 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL2993486 | 0.90 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL10220038 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL17541218 | 0.83 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL11302626 | 0.83 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL12838364 | 0.82 | GAA (0.74) | SMN1; SMN2ALDH1A1KMT2AHPGDKDM4E | |
| SCHEMBL11300020 | 0.82 | GAA (0.74) | SMN1; SMN2ALDH1A1KMT2AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642798-B2 | Silacycle compounds and methods of use thereof | THE TRUSTEE OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-02-04 | — | — | US | disclosed |
| US-20080167468-A1 | using the diastereomeric mixture of Silacycle Compounds for stereoselective synthesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167468-A1 | using the diastereomeric mixture of Silacycle Compounds for stereoselective synthesis | LSS, CYP51A1, DHPS | SMN1; SMN2 4380/4885ALDH1A1 1620/4885MEN1 741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.