Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669394 | 0.88 | GRM5 (0.36) | ACVR1BMPR1AACVRL1PARP1POLB | |
| SCHEMBL2669510 | 0.85 | ACVR1 (0.34) | TSHRMAPK10ACVR1BMPR1AACVRL1 | |
| SCHEMBL2656099 | 0.85 | PARP1 (0.35) | TSHRMAPK10ACVR1BMPR1AACVRL1 | |
| SCHEMBL2669534 | 0.85 | LCK (0.46) | TSHRMAPK10ACVR1BMPR1AACVRL1 | |
| SCHEMBL2669396 | 0.84 | PARP1 (0.35) | TSHRMAPK10ACVR1BMPR1AACVRL1 | |
| SCHEMBL2669509 | 0.84 | ACVR1 (0.40) | ACVR1BMPR1AACVRL1PARP1POLB | |
| SCHEMBL2669539 | 0.83 | MAPK1 (0.36) | TSHRMAPK10ACVR1BMPR1AACVRL1 | |
| SCHEMBL4921275 | 0.82 | GABRG2 (0.43) | TSHRMAPK10POLB | |
| SCHEMBL2669424 | 0.82 | MAPK1 (0.36) | TSHRMAPK10ACVR1BMPR1AACVRL1 | |
| SCHEMBL2661202 | 0.82 | TSHR (0.35) | TSHRMAPK10ACVR1BMPR1AACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | claimed |
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | COMT, BACE1, BDNF | TSHR 265/4885MAPK10 4168/4885ACVR1 4057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.