Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 5/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669510 | 0.90 | ACVR1 (0.34) | ACVR1BMPR1AACVRL1GRM5CDK4 | |
| SCHEMBL2661471 | 0.86 | HSD11B1 (0.36) | ACVR1BMPR1AACVRL1GRM5POLB | |
| SCHEMBL2669394 | 0.85 | GRM5 (0.36) | ACVR1BMPR1AACVRL1KDM4EALDH1A1 | |
| SCHEMBL4924879 | 0.84 | TSHR (0.35) | ACVR1BMPR1AACVRL1GRM5CDK5 | |
| SCHEMBL2669594 | 0.83 | BMPR1A (0.40) | ACVR1BMPR1AACVRL1POLBPARP1 | |
| SCHEMBL2656099 | 0.82 | PARP1 (0.35) | ACVR1BMPR1AACVRL1ALDH1A1GRM5 | |
| SCHEMBL2669534 | 0.82 | LCK (0.46) | ACVR1BMPR1AACVRL1 | |
| SCHEMBL2657795 | 0.81 | HSP90AA1 (0.39) | ACVR1BMPR1AACVRL1GRM5POLB | |
| SCHEMBL2661563 | 0.81 | ACVR1 (0.38) | ACVR1BMPR1AACVRL1POLBMAPK1 | |
| SCHEMBL2660782 | 0.81 | GABRG2 (0.42) | ACVR1BMPR1AACVRL1GRM5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | claimed |
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| WO-2008155572-A2 | FUSED QUINOLINE DERIVATIVES USEFUL AS GABA MODULATORS | ASTRAZENECA AB (SE) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | COMT, BACE1, BDNF | ACVR1 4057/4885BMPR1A 1929/4885ACVRL1 3949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.