Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA7 | P43166 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | SCD | O00767 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12336483 | 0.92 | CYP3A4 (0.56) | CYP3A4CA12CA1CA2CA7 | |
| SCHEMBL492368 | 0.90 | CYP3A4 (0.59) | CYP3A4CA12CA1CA2CA7 | |
| SCHEMBL906628 | 0.88 | CYP3A4 (0.61) | CYP3A4CA12CA1CA2CA7 | |
| SCHEMBL12336473 | 0.87 | CYP3A4 (0.60) | CYP3A4CA12CA1CA2CA7 | |
| SCHEMBL492858 | 0.87 | CYP3A4 (0.50) | CYP3A4CA12CA1CA2CA7 | |
| SCHEMBL12312848 | 0.87 | CYP3A4 (0.60) | CYP3A4CA12CA1CA2CA7 | |
| SCHEMBL12312849 | 0.87 | CYP3A4 (0.60) | CYP3A4CA12CA1CA2CA7 | |
| SCHEMBL492847 | 0.87 | CSF1R (0.60) | CYP3A4CA12CA1CA2CA7 | |
| SCHEMBL12957921 | 0.87 | CYP3A4 (0.51) | CYP3A4CA12CA1CA2CA7 | |
| SCHEMBL906848 | 0.87 | CYP3A4 (0.51) | CYP3A4CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10408819-B2 | Luminescence-based methods and probes for measuring cytochrome P450 activity | PROMEGA CORPORATION (US) | 2019-09-10 | — | — | US | disclosed |
| US-9814787-B2 | Luciferin amides | UNIVERSITY OF MASSACHUSETTS (US) | 2017-11-14 | — | — | US | disclosed |
| US-9814787-B2 | Luciferin amides | UNIVERSITY OF MASSACHUSETTS (US) | 2017-11-14 | — | — | US | disclosed |
| US-9814787-B2 | Luciferin amides | UNIVERSITY OF MASSACHUSETTS (US) | 2017-11-14 | — | — | US | disclosed |
| EP-2545041-B1 | BIOLUMINESCENT ASSAYS USING CYANOBENZOTHIAZOLE COMPOUNDS | PROMEGA CORP (US) | 2017-08-02 | — | — | EP | disclosed |
| US-20170191985-A1 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2017-07-06 | — | — | US | disclosed |
| US-9574223-B2 | Luminescence-based methods and probes for measuring cytochrome P450 activity | PROMEGA CORPORATION (US) | 2017-02-21 | — | — | US | disclosed |
| US-20160279268-A1 | Luciferin Amides | UNIVERSITY OF MASSACHUSETTS | 2016-09-29 | — | — | US | disclosed |
| US-20160279268-A1 | Luciferin Amides | UNIVERSITY OF MASSACHUSETTS | 2016-09-29 | — | — | US | disclosed |
| US-20160279268-A1 | Luciferin Amides | UNIVERSITY OF MASSACHUSETTS | 2016-09-29 | — | — | US | disclosed |
| US-20110223625-A1 | BIOLUMINESCENT ASSAYS USING CYANOBENZOTHIAZOLE COMPOUNDS | PROMEGA CORPORATION (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110223625-A1 | BIOLUMINESCENT ASSAYS USING CYANOBENZOTHIAZOLE COMPOUNDS | PROMEGA CORPORATION (US) | 2011-09-15 | — | — | US | disclosed |
| EP-1546162-B1 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | PROMEGA CORP (US) | 2011-06-22 | — | — | EP | disclosed |
| US-20110003316-A1 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | PROMEGA CORPORATION (US) | 2011-01-06 | — | — | US | disclosed |
| US-7692022-B2 | Using luciferin derivatives for analyzing metabolic activity in animals, cells or in cell-free reaction formulations | PROMEGA CORPORATION (US) | 2010-04-06 | — | — | US | disclosed |
| US-20090023173-A1 | Luminescence-based methods and probes for measuring cytochrome P450 activity | PROMEGA CORPORATION (US) | 2009-01-22 | — | — | US | disclosed |
| EP-1546162-A4 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | PROMEGA CORP (US) | 2007-07-18 | — | — | EP | disclosed |
| EP-1546162-A2 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | PROMEGA CORPORATION (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040171099-A1 | Using luciferin derivatives for analyzing metabolic activity in animals, cells or in cell-free reaction formulations | PROMEGA CORPORATION | 2004-09-02 | — | — | US | disclosed |
| WO-2004027378-A2 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | PROMEGA CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023173-A1 | Luminescence-based methods and probes for measuring cytochrome P450 activity | CYP3A43, CYP3A7, CYP3A5 | CYP3A4 18/4885CA12 3269/4885CA1 2908/4885 |
| US-20160279268-A1 | Luciferin Amides | FAAH, FAAH2, MGLL | CYP3A4 1336/4885CA12 3272/4885CA1 2029/4885 |
| US-10408819-B2 | Luminescence-based methods and probes for measuring cytochrome P450 activity | CYP3A7, CYP3A43, CYP3A5 | CYP3A4 22/4885CA12 3167/4885CA1 2799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.