Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.42 |
| ▸ | CA2 | P00918 | 5/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19393238 | 0.86 | LMNA (0.57) | CYP3A4KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL12312845 | 0.86 | CYP3A4 (0.46) | CYP3A4KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL29577024 | 0.86 | CYP3A4 (0.49) | CYP3A4KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL19393239 | 0.86 | LMNA (0.51) | CYP3A4KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL31303990 | 0.86 | CA1 (0.57) | CYP3A4KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL25337723 | 0.86 | CYP3A4 (0.49) | CYP3A4KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL12312843 | 0.86 | CA1 (0.57) | CYP3A4KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL906648 | 0.85 | CYP3A4 (0.44) | CYP3A4KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL12312858 | 0.85 | CA1 (0.50) | CYP3A4KMT2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL12617989 | 0.85 | CACNA1B (0.48) | CYP3A4KMT2AALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10408819-B2 | Luminescence-based methods and probes for measuring cytochrome P450 activity | PROMEGA CORPORATION (US) | 2019-09-10 | — | — | US | disclosed |
| EP-2545041-B1 | BIOLUMINESCENT ASSAYS USING CYANOBENZOTHIAZOLE COMPOUNDS | PROMEGA CORP (US) | 2017-08-02 | — | — | EP | disclosed |
| US-20170191985-A1 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2017-07-06 | — | — | US | disclosed |
| US-9574223-B2 | Luminescence-based methods and probes for measuring cytochrome P450 activity | PROMEGA CORPORATION (US) | 2017-02-21 | — | — | US | disclosed |
| EP-2331517-B1 | BIOLUMINESCENT ASSAYS USING CYANOBENZOTHIAZOLE COMPOUNDS | PROMEGA CORP (US) | 2016-06-08 | — | — | EP | disclosed |
| US-20140380514-A1 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2014-12-25 | — | — | US | disclosed |
| US-8765969-B2 | Luminescence-based methods and probes for measuring cytochrome P450 activity | PROMEGA CORPORATION (US) | 2014-07-01 | — | — | US | disclosed |
| US-8551721-B2 | Bioluminescent detection of cyanohydroxy benzothiazole compounds | PROMEGA CORPORATION (US) | 2013-10-08 | — | — | US | disclosed |
| US-8551721-B2 | Bioluminescent detection of cyanohydroxy benzothiazole compounds | PROMEGA CORPORATION (US) | 2013-10-08 | — | — | US | disclosed |
| US-8106052-B2 | Luminescence-based methods and probes for measuring cytochrome P450 activity | PROMEGA CORPORATION (US) | 2012-01-31 | — | — | US | disclosed |
| US-20110003316-A1 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | PROMEGA CORPORATION (US) | 2011-01-06 | — | — | US | disclosed |
| US-7692022-B2 | Using luciferin derivatives for analyzing metabolic activity in animals, cells or in cell-free reaction formulations | PROMEGA CORPORATION (US) | 2010-04-06 | — | — | US | disclosed |
| US-20100075351-A1 | BIOLUMINESCENT DETECTION OF CYANOHYDROXY BENZOTHIAZOLE COMPOUNDS | PROMEGA CORPORATION (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075351-A1 | BIOLUMINESCENT DETECTION OF CYANOHYDROXY BENZOTHIAZOLE COMPOUNDS | PROMEGA CORPORATION (US) | 2010-03-25 | — | — | US | disclosed |
| WO-2010030343-A1 | BIOLUMINESCENT ASSAYS USING CYANOBENZOTHIAZOLE COMPOUNDS | PROMEGA CORPORATION (US) | 2010-03-18 | — | — | WO | disclosed |
| US-20090023173-A1 | Luminescence-based methods and probes for measuring cytochrome P450 activity | PROMEGA CORPORATION (US) | 2009-01-22 | — | — | US | disclosed |
| EP-1546162-A4 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | PROMEGA CORP (US) | 2007-07-18 | — | — | EP | disclosed |
| EP-1546162-A2 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | PROMEGA CORPORATION (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040171099-A1 | Using luciferin derivatives for analyzing metabolic activity in animals, cells or in cell-free reaction formulations | PROMEGA CORPORATION | 2004-09-02 | — | — | US | disclosed |
| WO-2004027378-A2 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | PROMEGA CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140380514-A1 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY | CYP3A43, CYP3A7, CYP3A5 | CYP3A4 18/4885KMT2A 4413/4885ALDH1A1 239/4885 |
| US-20100075351-A1 | BIOLUMINESCENT DETECTION OF CYANOHYDROXY BENZOTHIAZOLE COMPOUNDS | BLVRB, BTD, BBOX1 | CYP3A4 196/4885KMT2A 1983/4885ALDH1A1 650/4885 |
| US-20090023173-A1 | Luminescence-based methods and probes for measuring cytochrome P450 activity | CYP3A43, CYP3A7, CYP3A5 | CYP3A4 18/4885KMT2A 4413/4885ALDH1A1 239/4885 |
| US-10408819-B2 | Luminescence-based methods and probes for measuring cytochrome P450 activity | CYP3A7, CYP3A43, CYP3A5 | CYP3A4 22/4885KMT2A 3905/4885ALDH1A1 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.