SCHEMBL4928148

SCHEMBL4928148

C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(C)=O)[C@H](O)[C@@]2(C)O1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADCY1 Q08828 14/20 0.80
MAPK1 P28482 5/20 0.80
CYP3A4 P08684 4/20 0.80
TSHR P16473 3/20 0.80
NR1I2 O75469 2/20 0.80
ADRA1A P35348 2/20 0.80
KMT2A Q03164 2/20 0.80
CYP2C19 P33261 2/20 0.80
GMNN O75496 1/20 0.80
BLM P54132 1/20 0.80
PMP22 Q01453 1/20 0.80
NPSR1 Q6W5P4 1/20 0.80
CYP2D6 P10635 1/20 0.80
NFKB1 P19838 1/20 0.80
HIF1A Q16665 1/20 0.80
CHRM2 P08172 1/20 0.80
ABCB1 P08183 1/20 0.80
HTR1A P08908 1/20 0.80
ADRA2A P08913 1/20 0.80
SLC2A1 P11166 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8240684 1.00 ADCY1 (0.80) ADCY1MAPK1CYP3A4TSHRNR1I2
SCHEMBL11118724 1.00 ADCY1 (0.80) ADCY1MAPK1CYP3A4TSHRNR1I2
SCHEMBL30763213 0.94 ADCY1 (0.87) ADCY1MAPK1CYP3A4TSHRNR1I2
SCHEMBL11542815 0.94 ADCY1 (0.87) ADCY1MAPK1CYP3A4TSHRNR1I2
SCHEMBL8640465 0.91 ADCY1 (0.76) ADCY1MAPK1CYP3A4TSHRNR1I2
SCHEMBL8500754 0.90 ADCY1 (0.82) ADCY1MAPK1CYP3A4TSHRNR1I2
SCHEMBL11538072 0.90 ADCY1 (0.77) ADCY1MAPK1CYP3A4TSHRNR1I2
SCHEMBL9301783 0.90 ADCY1 (0.82) ADCY1MAPK1CYP3A4TSHRNR1I2
SCHEMBL8500908 0.90 ADCY1 (0.82) ADCY1MAPK1CYP3A4TSHRNR1I2
SCHEMBL9631043 0.90 ADCY1 (0.79) ADCY1MAPK1CYP3A4TSHRNR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119564664-A Application of isoforskolin in preparing medicament for treating diabetic cardiomyopathy 昆明医科大学第一附属医院(云南省皮肤病医院) 2025-03-07 CN claimed
CN-119386003-A Application of isoforskolin in preparation of atherosclerosis-inhibiting drugs 昆明医科大学第一附属医院(云南省皮肤病医院) 2025-02-07 CN claimed
CN-118777484-A Different from coleus forskohlii medicinal material method for measuring forskolin 湖北福人药业股份有限公司 2024-10-15 CN claimed
US-20240148686-A1 PHARMACEUTICAL COMPOSITION OF FORSKOLIN-ISOFORSKOLIN AND PENTACYCLIC TRITERPENOID COMPOUND, AND APPLICATION THEREOF CHINA PHARMACEUTICAL UNIVERSITY (CN) 2024-05-09 US claimed
CN-114814006-B Method for measuring content of chemical components in patchouli leaf 天津中医药大学 2023-06-06 CN claimed
CN-115414348-A Application of forskolin and derivatives thereof in preparation of medicine for treating psoriasis 昆明医科大学 2022-12-02 CN claimed
CN-113116955-B Pharmaceutical composition containing plant extracts and application thereof 中国药科大学 2022-10-04 CN claimed
CN-113244405-B Pharmaceutical composition of forskolin/isoforskolin and pentacyclic triterpenoid and application thereof 中国药科大学 2022-06-21 CN claimed
US-4782082-A BRONCHODILATORS, ANTIHISTAMINES SCHERING CORPORATION (US) 1988-11-01 US claimed
EP-0116713-A1 Novel labdane derivatives, process for the preparation thereof, and pharmaceutical compositions containing labdane derivatives SCHERING CORPORATION (US) 1984-08-29 EP claimed
CN-121698842-A Preparation method of 6-acetyl forskolin 云南省药物研究所 2026-03-20 CN disclosed
CN-121698841-A Preparation method of 1-acetyl isoforskolin 云南省药物研究所 2026-03-20 CN disclosed
CN-121698841-A Preparation method of 1-acetyl isoforskolin 云南省药物研究所 2026-03-20 CN disclosed
CN-119564664-A Application of isoforskolin in preparing medicament for treating diabetic cardiomyopathy 昆明医科大学第一附属医院(云南省皮肤病医院) 2025-03-07 CN disclosed
CN-119564664-A Application of isoforskolin in preparing medicament for treating diabetic cardiomyopathy 昆明医科大学第一附属医院(云南省皮肤病医院) 2025-03-07 CN disclosed
US-11234957-B2 Process for preparing water soluble forskolin SciPharm S.à.r.l (LU) 2022-02-01 US disclosed
US-20210220322-A1 Disease Modifying Methods For Treating Neurodegenerative Diseases Using Nootropic Agents BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO 2021-07-22 US disclosed
US-20080226571-A1 Compositions and methods to effect enhanced photoprotection against UV A and UV B induced damage of human skin MAJEED MUHAMMED 2008-09-18 US disclosed
US-20080226571-A1 Compositions and methods to effect enhanced photoprotection against UV A and UV B induced damage of human skin MAJEED MUHAMMED 2008-09-18 US disclosed
EP-0116713-A1 Novel labdane derivatives, process for the preparation thereof, and pharmaceutical compositions containing labdane derivatives SCHERING CORPORATION (US) 1984-08-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240148686-A1 PHARMACEUTICAL COMPOSITION OF FORSKOLIN-ISOFORSKOLIN AND PENTACYCLIC TRITERPENOID COMPOUND, AND APPLICATION THEREOF CYP11B2, PRKAR2B, GPR119 ADCY1 568/4885MAPK1 1188/4885CYP3A4 1532/4885
US-20210220322-A1 Disease Modifying Methods For Treating Neurodegenerative Diseases Using Nootropic Agents INA, BDNF, GAP43 ADCY1 7/4885MAPK1 2804/4885CYP3A4 4613/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.