Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 5/20 | 0.53 |
| ▸ | CA2 | P00918 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10874890 | 0.94 | LOXL2 (0.60) | LOXL2LMNAHPGDCYP4A11CYP4F2 | |
| SCHEMBL3310683 | 0.90 | LMNA (0.64) | LOXL2LMNAHPGDCYP4A11CYP4F2 | |
| SCHEMBL9016956 | 0.86 | LMNA (0.68) | LOXL2LMNAHPGDCYP4A11CYP4F2 | |
| SCHEMBL4928792 | 0.85 | CYP4A11 (0.66) | LOXL2LMNAHPGDCYP4A11CYP4F2 | |
| SCHEMBL15270260 | 0.85 | S1PR1 (0.57) | LOXL2LMNAHPGDCYP4A11CYP4F2 | |
| SCHEMBL13378249 | 0.85 | LMNA (0.59) | LOXL2LMNAHPGDCYP4A11CYP4F2 | |
| SCHEMBL7251467 | 0.85 | LOXL2 (0.83) | LOXL2LMNAHPGDCYP4A11CYP4F2 | |
| SCHEMBL28206352 | 0.85 | CYP4A11 (0.60) | LOXL2LMNAHPGDCYP4A11CYP4F2 | |
| Hydrochloric Acid SCHEMBL15393160 | 0.84 | LMNA (0.66) | LOXL2LMNAHPGDCYP4A11CYP4F2 | |
| SCHEMBL24140330 | 0.84 | CYP4A11 (0.67) | LOXL2LMNAHPGDCYP4A11CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |