Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929526 | 1.00 | CTSK (0.46) | CTSKCTSSLMNAPTPN1KLK5 | |
| SCHEMBL4917991 | 0.90 | CTSS (0.46) | CTSKCTSSLMNAPTPN1KLK5 | |
| SCHEMBL4917998 | 0.90 | CTSS (0.46) | CTSKCTSSLMNAPTPN1KLK5 | |
| SCHEMBL4924335 | 0.84 | CTSS (0.44) | CTSKCTSSPTPN1KLK5SCN9A | |
| SCHEMBL4924346 | 0.84 | CTSS (0.44) | CTSKCTSSPTPN1KLK5SCN9A | |
| SCHEMBL4923180 | 0.84 | CTSS (0.44) | CTSKCTSSPTPN1KLK5SCN9A | |
| SCHEMBL4923188 | 0.84 | CTSS (0.44) | CTSKCTSSPTPN1KLK5SCN9A | |
| SCHEMBL4597919 | 0.83 | LMNA (0.42) | LMNACCR1MAPTNPSR1 | |
| SCHEMBL4598158 | 0.83 | CTSS (0.52) | CTSKCTSSLMNAPTPN1SCN9A | |
| Hydrochloric Acid SCHEMBL4928097 | 0.82 | LMNA (0.41) | LMNACCR1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910274-B1 | PHENYL COMPOUNDS | LILLY CO ELI (US) | 2012-08-08 | — | — | EP | disclosed |
| US-8076514-B2 | Dipeptidyl peptidase IV inhibitors; Type II diabetes; 2-[(2S,3R)-3-Amino-2-hydroxy-4-(2,4,5-trifluoro-phenyl)-butyl]-N-tert-butyl-4-chloro-benzamide Hydrochloride | ELI LILLY AND COMPANY (US) | 2011-12-13 | — | — | US | disclosed |
| US-20080221217-A1 | Phenyl Compounds and Their Use in the Treatment of Type II Diabetes | ELI LILLY AND COMPANY | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221217-A1 | Phenyl Compounds and Their Use in the Treatment of Type II Diabetes | DPP4, GPR119, SLC5A2 | CTSK 2871/4885CTSS 2054/4885LMNA 3446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.