Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 16/20 | 0.49 |
| ▸ | THRA | P10827 | 14/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930757 | 0.91 | THRB (0.49) | THRBTHRAPPARDMMEACE | |
| SCHEMBL4357774 | 0.89 | THRA (0.64) | THRBTHRA | |
| SCHEMBL4926924 | 0.89 | PPARD (0.45) | THRBTHRATRPA1PPARDMME | |
| SCHEMBL5116916 | 0.88 | THRB (0.50) | THRBTHRAPPARD | |
| SCHEMBL4922875 | 0.88 | THRB (0.52) | THRBTHRAPPARD | |
| SCHEMBL5118031 | 0.87 | THRB (0.47) | THRBTHRAMMEACECPA1 | |
| SCHEMBL4929444 | 0.86 | ALDH1A1 (0.46) | THRBTHRATRPA1MMEACE | |
| SCHEMBL4930958 | 0.86 | THRA (0.44) | THRBTHRATRPA1MMEACE | |
| SCHEMBL4930674 | 0.86 | THRB (0.53) | THRBTHRATRPA1PPARD | |
| SCHEMBL4934248 | 0.85 | THRA (0.44) | THRBTHRATRPA1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221210-A1 | Thyroid Receptor Agonists | KARO BIO AB (SE) | 2008-09-11 | — | — | US | disclosed |
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221210-A1 | Thyroid Receptor Agonists | TSHR, TRHR, THRA | THRB 4/4885THRA 3/4885TRPA1 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.