SCHEMBL4930906

SCHEMBL4930906

Cc1cccnc1-c1c(Cl)nc2ncnn2c1Cl

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.40
ALDH1A1 P00352 3/20 0.39
KDM4E B2RXH2 3/20 0.37
PKM P14618 1/20 0.36
MAPT P10636 1/20 0.36
MAPK1 P28482 1/20 0.36
CYP2A6 P11509 1/20 0.35
CRHR1 P34998 1/20 0.34
PDE2A O00408 1/20 0.34
KMT2A Q03164 2/20 0.34
SMO Q99835 1/20 0.34
ENPP1 P22413 1/20 0.34
MEN1 O00255 1/20 0.34
POLB P06746 1/20 0.34
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5442886 0.81 MBOAT4 (0.40) ALDH1A1KDM4EPDE2APOLB
SCHEMBL4928661 0.79 ALDH1A1 (0.41) USP2ALDH1A1MAPTMAPK1PDE2A
SCHEMBL8127031 0.74 ALDH1A1 (0.52) ALDH1A1KDM4EPKMMAPTMAPK1
SCHEMBL4935032 0.74 KDM4E (0.41) ALDH1A1KDM4EPKMMAPTMAPK1
SCHEMBL4926421 0.74 CCR1 (0.43) ALDH1A1KDM4EPKMMAPTMAPK1
SCHEMBL868326 0.74 KDM4E (0.49) USP2ALDH1A1KDM4EMAPTMAPK1
SCHEMBL8117996 0.71 KDM4E (0.47) ALDH1A1KDM4EMAPTMAPK1PDE2A
SCHEMBL8124142 0.71 EGLN2 (0.47) USP2ALDH1A1KDM4EMAPTMAPK1
SCHEMBL5622818 0.71 ALDH1A1 (0.39) ALDH1A1KDM4EKMT2AMEN1POLB
SCHEMBL8686955 0.71 ALDH1A1 (0.47) ALDH1A1KDM4EPKMMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080227796-A1 7-Amino-6-Hetaryl-1,2,4-Triazolo[1,5-A]Pyrimidine Compounds and the Use Thereof for Controlling Pathogenic Fungi BASF AKTIENGESELLSCHAFT (DE) 2008-09-18 US disclosed
EP-1828191-A2 7-AMINO-6-HETARYL-1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AND THE USE THEREOF FOR CONTROLLING PATHOGENIC FUNGI BASF AKTIENGESELLSCHAFT (DE) 2007-09-05 EP disclosed
WO-2006066818-A2 7-AMINO-6-HETARYL-1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AND THE USE THEREOF FOR CONTROLLING PATHOGENIC FUNGI BASF AKTIENGESELLSCHAFT (DE) 2006-06-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227796-A1 7-Amino-6-Hetaryl-1,2,4-Triazolo[1,5-A]Pyrimidine Compounds and the Use Thereof for Controlling Pathogenic Fungi CYP8B1, CBR3, HDHD5 USP2 2847/4885ALDH1A1 2419/4885KDM4E 4114/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.