Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929719 | 0.89 | KMT2A (0.62) | SMN1; SMN2KMT2AMEN1GPR119HDAC4 | |
| SCHEMBL4929304 | 0.88 | KMT2A (0.60) | SMN1; SMN2KMT2AMEN1HDAC4ABL1 | |
| SCHEMBL474172 | 0.83 | KMT2A (0.46) | SMN1; SMN2USP2KMT2AMEN1GPR119 | |
| SCHEMBL14154600 | 0.83 | GPR119 (0.55) | SMN1; SMN2USP2KMT2AMEN1GPR119 | |
| SCHEMBL31705318 | 0.82 | KMT2A (0.47) | KMT2AMEN1GPR119 | |
| SCHEMBL1473518 | 0.81 | KDM4E (0.51) | KMT2AMEN1GPR119KDM4E | |
| SCHEMBL14338856 | 0.81 | NR1H2 (0.45) | KMT2AMEN1GPR119JAK2JAK1 | |
| SCHEMBL19598956 | 0.80 | GPR119 (0.52) | GPR119 | |
| SCHEMBL14720577 | 0.78 | ATM (0.49) | SMN1; SMN2KMT2AMEN1GPR119ALDH1A1 | |
| SCHEMBL1602493 | 0.78 | GPR119 (0.50) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176903-A1 | Novel Compounds with Analgesic Effect | ASTRAZENECA CANADA INC. (CA) | 2008-07-24 | — | — | US | disclosed |
| US-7312336-B2 | Compounds with analgesic effect | ASTRAZENECA CANADA INC. (CA) | 2007-12-25 | — | — | US | disclosed |
| EP-0946511-B1 | NOVEL COMPOUNDS WITH ANALGESIC EFFECT | ASTRAZENECA AB (SE) | 2005-05-25 | — | — | EP | disclosed |
| US-20040171612-A1 | Novel compounds with analgesic effect | ASTRAZENECA CANADA INC. | 2004-09-02 | — | — | US | disclosed |
| US-6693117-B2 | PIPERIDIN-4-YLIDENE DERIVATIVES | ASTRAZENECA CANADA INC. (CA) | 2004-02-17 | — | — | US | disclosed |
| US-20030149023-A1 | Novel compounds with analgesic effect | ASTRAZENECA CANADA INC. | 2003-08-07 | — | — | US | disclosed |
| US-6455545-B2 | GASTROINTESTINAL DISORDERS | ASTRAZENECA CANADA INC. (CA) | 2002-09-24 | — | — | US | disclosed |
| US-20010021715-A1 | Novel compounds with analgesic effect | ASTRA PHARMA INC. | 2001-09-13 | — | — | US | disclosed |
| US-6187792-B1 | PIPERIDIN-4-METHYLIDENE-4-BENZAMIDE DERIVATIVES; OPOID RECEPTOR ANTAGONISTS; CANCER PAIN | ASTRA PHARMA INC. (CA) | 2001-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010021715-A1 | Novel compounds with analgesic effect | OPRL1, OPRK1, OPRM1 | SMN1; SMN2 235/4885USP2 4213/4885KMT2A 4601/4885 |
| US-20030149023-A1 | Novel compounds with analgesic effect | OPRL1, OPRK1, OPRM1 | SMN1; SMN2 235/4885USP2 4213/4885KMT2A 4601/4885 |
| US-20080176903-A1 | Novel Compounds with Analgesic Effect | OPRL1, OPRK1, OPRM1 | SMN1; SMN2 337/4885USP2 3987/4885KMT2A 4562/4885 |
| US-20040171612-A1 | Novel compounds with analgesic effect | OPRL1, OPRK1, OPRM1 | SMN1; SMN2 235/4885USP2 4213/4885KMT2A 4601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.