Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 6/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.56 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | TDP2 | O95551 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187369 | 0.85 | XDH (0.57) | XDHSLC22A12CNR1TDP2KCNH2 | |
| SCHEMBL4162173 | 0.83 | XDH (0.58) | XDHSLC22A12CNR1TDP2KDR | |
| SCHEMBL4187435 | 0.80 | XDH (0.56) | XDHSLC22A12CNR1TDP2KCNH2 | |
| SCHEMBL4154749 | 0.78 | ROCK2 (0.51) | CNR1KDRALPLMAP4K4 | |
| SCHEMBL4195748 | 0.78 | KCNH2 (0.52) | XDHSLC22A12CNR1TDP2KCNH2 | |
| SCHEMBL4191619 | 0.78 | XDH (0.54) | XDHSLC22A12CNR1ALPL | |
| SCHEMBL10570649 | 0.78 | KMT2A (0.61) | SCN9AKDRESR1MEN1KMT2A | |
| SCHEMBL4154890 | 0.77 | XDH (0.60) | XDHSLC22A12CNR1TDP2KCNH2 | |
| SCHEMBL4929361 | 0.76 | KMT2A (0.66) | CNR1MEN1KMT2AMAPTMAP4K4 | |
| SCHEMBL4920244 | 0.76 | ALDH1A1 (0.66) | ALPLCYP3A4CYP2D6PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | GALAPAGOS NV (BE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | ROCK1, TNK2, GRK1 | XDH 407/4885SLC22A12 4756/4885CNR1 1765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.