Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | ALPL | P05186 | 6/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211823 | 0.78 | ALPL (1.00) | ALPL | |
| SCHEMBL4931253 | 0.76 | XDH (0.56) | ALPLCYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL9568492 | 0.75 | KMT2A (0.72) | ALDH1A1ALPLCYP3A4CYP2D6HTT | |
| SCHEMBL3665383 | 0.74 | PIK3CG (1.00) | PIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL16529326 | 0.74 | CYP3A4 (0.56) | ALDH1A1CYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL30828581 | 0.73 | ALDH1A1 (0.73) | ALDH1A1CYP3A4CYP2D6PSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL939057 | 0.73 | PIK3CG (0.98) | PIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL2118369 | 0.73 | ALDH1A1 (0.56) | ALDH1A1CYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL4195479 | 0.73 | APP (0.61) | ALDH1A1CYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL14689318 | 0.72 | MEN1 (0.60) | ALDH1A1PIK3CACES1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | GALAPAGOS NV (BE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | ROCK1, TNK2, GRK1 | ALDH1A1 3779/4885ALPL 2276/4885CYP3A4 1134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.