Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | CCR1 | P32246 | 3/20 | 0.32 |
| ▸ | CCR8 | P51685 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13192813 | 0.76 | LMNA (0.52) | LMNAMTORHSP90AA1L3MBTL1NPC1 | |
| SCHEMBL1727666 | 0.75 | KDM4E (0.52) | KDM4E | |
| SCHEMBL30951595 | 0.75 | KDM4E (0.52) | KDM4E | |
| SCHEMBL10667809 | 0.74 | LMNA (0.59) | LMNAMTORHSP90AA1L3MBTL1NPC1 | |
| SCHEMBL4900470 | 0.74 | KDM4E (0.47) | LMNAMTORHSP90AA1L3MBTL1NPC1 | |
| SCHEMBL729398 | 0.74 | LMNA (0.45) | LMNAMTORPIK3CAHSP90AA1L3MBTL1 | |
| Bromide SCHEMBL10699147 | 0.72 | LMNA (0.58) | LMNAMTORHSP90AA1NPC1KDM4E | |
| Iodide SCHEMBL10698948 | 0.72 | LMNA (0.58) | LMNAMTORHSP90AA1NPC1KDM4E | |
| SCHEMBL7678 | 0.71 | — | — | |
| SCHEMBL5572937 | 0.70 | DHFR (0.42) | LMNAHSP90AA1HCAR2NUDT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110294799-A1 | Organic Compounds | NOVARTIS AG | 2011-12-01 | — | — | US | disclosed |
| US-20080021056-A1 | Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase | ELAN PHARMACEUTICALS, INC. | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294799-A1 | Organic Compounds | SLCO4C1, SLCO1B1, SLCO1B3 | LMNA 2266/4885MTOR 2444/4885PIK3CA 1863/4885 |
| US-20080021056-A1 | Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase | BACE1, BACE2, PSEN1 | LMNA 1368/4885MTOR 540/4885PIK3CA 435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.