Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493819 | 0.91 | SMYD3 (0.52) | CYP3A4HPGDCYP2C19RAB9AMAOA | |
| SCHEMBL493817 | 0.89 | CYP3A4 (0.46) | CYP3A4HPGDCYP2C19RAB9AMAOA | |
| SCHEMBL1326524 | 0.85 | HPGD (0.45) | CYP3A4HPGDCYP2C19RAB9AMAOA | |
| SCHEMBL28810401 | 0.84 | TSHR (0.48) | CYP3A4HPGDCYP2C19RAB9AKMT2A | |
| SCHEMBL493316 | 0.83 | TSHR (0.42) | CYP3A4HPGDCYP2C19RAB9AMAOA | |
| Cyclohexane SCHEMBL2304945 | 0.83 | TSHR (0.50) | CYP3A4HPGDCYP2C19RAB9AKMT2A | |
| Cyclopentane SCHEMBL2306640 | 0.83 | TSHR (0.50) | CYP3A4HPGDCYP2C19RAB9AKMT2A | |
| SCHEMBL1326686 | 0.82 | LMNA (0.61) | KMT2AOPRM1OPRL1EPHX2LMNA | |
| SCHEMBL2308758 | 0.82 | TSHR (0.47) | CYP3A4HPGDCYP2C19RAB9ATSHR | |
| SCHEMBL2307354 | 0.82 | MEN1 (0.52) | RAB9AKMT2ASMYD3SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | CYP3A4 465/4885HPGD 213/4885CYP2C19 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.