Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | MARS1 | P56192 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4931612 | 0.90 | MARS1 (0.51) | NFE2L2MARS1MEN1KMT2ASLC16A3 | |
| SCHEMBL4926726 | 0.89 | ALDH1A1 (0.41) | NFE2L2MARS1CNR1CNR2ALDH1A1 | |
| SCHEMBL5529669 | 0.87 | CNR1 (0.50) | NFE2L2MARS1CNR1CNR2MEN1 | |
| SCHEMBL4933639 | 0.84 | FYN (0.48) | MARS1SLC16A3SLC16A1MAPK1SMN1; SMN2 | |
| SCHEMBL4923262 | 0.83 | CYP3A4 (0.44) | NFE2L2MARS1CNR1CNR2ALDH1A1 | |
| SCHEMBL4932389 | 0.82 | MGLL (0.49) | MEN1KMT2ASMN1; SMN2PTGS2MGLL | |
| SCHEMBL14563991 | 0.82 | NPC1 (0.40) | NFE2L2ALDH1A1SLC16A3SLC16A1FYN | |
| SCHEMBL2919388 | 0.81 | SMN1; SMN2 (0.39) | MEN1KMT2ASMN1; SMN2PTGS2FAAH | |
| SCHEMBL5162928 | 0.81 | ALDH1A1 (0.38) | MARS1ALDH1A1PTGS2MGLLGRM1 | |
| SCHEMBL31130418 | 0.78 | SLC16A3 (0.61) | MARS1SLC16A3SLC16A1MAPK1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064682-A1 | Pyrazole Derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-03-13 | — | — | US | disclosed |
| US-20070219210-A1 | Amidopyrazole Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-09-20 | — | — | US | disclosed |
| EP-1762568-A1 | PYRAZOLE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-03-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064682-A1 | Pyrazole Derivatives | NAT1, AR, CBR3 | NFE2L2 2680/4885MARS1 760/4885CNR1 44/4885 |
| US-20070219210-A1 | Amidopyrazole Derivative | PTGER1, PTGS1, PTGER2 | NFE2L2 1332/4885MARS1 2982/4885CNR1 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.