Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934011 | 0.89 | SMN1; SMN2 (0.40) | SMN1; SMN2ADRB2ADRB1ADRB3CES2 | |
| SCHEMBL28175044 | 0.80 | TP53 (0.38) | SMN1; SMN2HTTKMT2AALDH1A1POLB | |
| SCHEMBL776049 | 0.78 | ALDH1A1 (0.43) | SMN1; SMN2ADRB2ADRB1ADRB3CES2 | |
| SCHEMBL777338 | 0.77 | CES2 (0.37) | SMN1; SMN2ADRB2ADRB1ADRB3CES2 | |
| SCHEMBL7807159 | 0.77 | ALDH1A1 (0.46) | SMN1; SMN2ADRB2ADRB1ADRB3CES2 | |
| SCHEMBL386768 | 0.77 | CES2 (0.50) | SMN1; SMN2ADRB2ADRB1ADRB3CES2 | |
| SCHEMBL18126504 | 0.75 | NAAA (0.44) | SMN1; SMN2CES2CES1HDAC8HDAC6 | |
| SCHEMBL777438 | 0.75 | CES2 (0.41) | SMN1; SMN2ADRB2ADRB1ADRB3CES2 | |
| SCHEMBL28538091 | 0.75 | CES2 (0.41) | SMN1; SMN2ADRB2ADRB1ADRB3CES2 | |
| SCHEMBL11862575 | 0.74 | CES2 (0.55) | SMN1; SMN2CES2CES1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080021058-A1 | Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021058-A1 | Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors | PDE4A, PDE4B, PDE3B | SMN1; SMN2 4160/4885ADRB2 86/4885ADRB1 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.