Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934358 | 1.00 | THRB (0.61) | THRBALDH1A1NPSR1TBXAS1POLB | |
| SCHEMBL11062417 | 0.87 | TBXAS1 (0.71) | THRBALDH1A1TBXAS1POLBKDM4E | |
| SCHEMBL11062411 | 0.87 | TBXAS1 (0.71) | THRBALDH1A1TBXAS1POLBKDM4E | |
| SCHEMBL3928106 | 0.84 | HDAC1 (0.64) | THRBALDH1A1POLBKDM4EHPGD | |
| SCHEMBL3928110 | 0.84 | HDAC1 (0.64) | THRBALDH1A1POLBKDM4EHPGD | |
| SCHEMBL2184878 | 0.81 | KDM4E (0.67) | POLBCYP1A2CYP2D6TDP1KDM4E | |
| SCHEMBL16585159 | 0.81 | KDM4E (0.67) | POLBCYP1A2CYP2D6TDP1KDM4E | |
| SCHEMBL2184876 | 0.81 | KDM4E (0.67) | POLBCYP1A2CYP2D6TDP1KDM4E | |
| SCHEMBL15341319 | 0.79 | CA12 (0.55) | KDM4EHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4933047 | 0.78 | ALDH1A1 (0.66) | ALDH1A1NPSR1POLBCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070954-A1 | Acylurea Connected And Sulfonylurea Connected Hydroxamates | S*BIO PTE LTD. (SG) | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070954-A1 | Acylurea Connected And Sulfonylurea Connected Hydroxamates | HDAC1, HDAC3, HDAC4 | THRB 3473/4885ALDH1A1 1020/4885NPSR1 3988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.