Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 15/20 | 0.47 |
| ▸ | THRA | P10827 | 13/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4926344 | 0.90 | THRA (0.60) | THRBTHRA | |
| SCHEMBL4932229 | 0.90 | PPARD (0.43) | THRBTHRAMRGPRX4PPARDRXRA | |
| SCHEMBL4931986 | 0.87 | THRA (0.42) | THRBTHRAMRGPRX4S1PR1 | |
| SCHEMBL4932002 | 0.86 | THRB (0.50) | THRBTHRAPTPN1 | |
| SCHEMBL4932240 | 0.86 | THRA (0.42) | THRBTHRAMRGPRX4S1PR1 | |
| SCHEMBL4929949 | 0.85 | THRA (0.41) | THRBTHRAMRGPRX4S1PR1 | |
| SCHEMBL5718494 | 0.85 | MEN1 (0.37) | THRBTHRAMRGPRX4PPARD | |
| SCHEMBL5718319 | 0.85 | THRB (0.51) | THRBTHRAPTPN1 | |
| SCHEMBL4932765 | 0.84 | THRB (0.50) | THRBTHRAPTPN1 | |
| SCHEMBL4929184 | 0.84 | THRB (0.47) | THRBTHRAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221210-A1 | Thyroid Receptor Agonists | KARO BIO AB (SE) | 2008-09-11 | — | — | US | disclosed |
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221210-A1 | Thyroid Receptor Agonists | TSHR, TRHR, THRA | THRB 4/4885THRA 3/4885MRGPRX4 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.