SCHEMBL493460

SCHEMBL493460

CCOc1ccc(C=O)cc1Br

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 13/20 0.60
LMNA P02545 1/20 0.54
TACR2 P21452 1/20 0.52
ALDH1A3 P47895 2/20 0.51
KDM4E B2RXH2 1/20 0.51
HPGD P15428 3/20 0.49
TDP1 Q9NUW8 3/20 0.49
L3MBTL1 Q9Y468 3/20 0.49
MAPT P10636 3/20 0.49
NPSR1 Q6W5P4 1/20 0.49
ALDH3A1 P30838 1/20 0.49
FDPS P14324 1/20 0.49
SMN1; SMN2 Q16637 2/20 0.48
NPC1 O15118 1/20 0.48
HTT P42858 1/20 0.48
RAB9A P51151 1/20 0.48
TSHR P16473 1/20 0.47
AOX1 Q06278 1/20 0.43
GAA P10253 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL177168 0.86 FDPS (0.54) ALDH1A1LMNAALDH1A3KDM4EHPGD
SCHEMBL8024512 0.85 FDPS (0.53) ALDH1A1LMNAALDH1A3KDM4EHPGD
SCHEMBL493684 0.83 ALDH1A1 (0.73) ALDH1A1LMNATACR2KDM4EHPGD
SCHEMBL30159697 0.83 ALDH1A1 (0.73) ALDH1A1LMNATACR2KDM4EHPGD
SCHEMBL349177 0.83 MAPT (0.50) ALDH1A1LMNAALDH1A3KDM4EHPGD
SCHEMBL29886954 0.83 MAPT (0.50) ALDH1A1LMNAALDH1A3KDM4EHPGD
SCHEMBL14195842 0.82 THRA (0.51) ALDH1A1ALDH1A3KDM4EHPGDMAPT
SCHEMBL16955613 0.82 ALDH1A1 (0.46) ALDH1A1LMNAHPGDTDP1L3MBTL1
SCHEMBL16950571 0.82 HPGD (0.46) ALDH1A1LMNAHPGDTDP1L3MBTL1
SCHEMBL4959651 0.81 FDPS (0.61) ALDH1A1LMNAALDH1A3KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2199290-B1 Method of nucleating a polyolefin composition with acetal-based compounds MILLIKEN & CO (US) 2018-06-06 EP claimed
EP-2663542-B1 PROCESS FOR THE PREPARATION OF ALDITOL ACETALS RELIANCE IND LTD (IN) 2016-07-06 EP claimed
US-9029575-B2 Process for preparation of acetals RELIANCE INDUSTRIES LIMITED (IN) 2015-05-12 US claimed
US-8969595-B2 Method of making diacetal compound in aqueous medium RELIANCE INDUSTRIES LIMITED (IN) 2015-03-03 US claimed
US-8871954-B2 Process for the preparation of alditol acetals RELIANCE INDUSTRIES LIMITED (IN) 2014-10-28 US claimed
EP-2663542-A1 PROCESS FOR THE PREPARATION OF ALDITOL ACETALS Reliance Industries Limited (IN) 2013-11-20 EP claimed
EP-2663569-A1 PROCESS FOR PREPARING ALDITOL ACETALS Reliance Industries Limited (IN) 2013-11-20 EP claimed
EP-2663568-A1 PROCESS FOR PREPARATION OF ACETALS Reliance Industries Limited (IN) 2013-11-20 EP claimed
CN-103402960-A Process for the preparation of alditol acetals RELIANCE IND LTD 2013-11-20 CN claimed
CN-103402959-A Method of making diacetal compound in aqueous medium RELIANCE IND LTD 2013-11-20 CN claimed
EP-2199290-A2 Method of nucleating a polyolefin composition with acetal-based compounds Milliken & Company (US) 2010-06-23 EP claimed
US-7262236-B2 Acetal-based compositions MILLIKEN & COMPANY (US) 2007-08-28 US claimed
EP-1740653-A4 METHOD OF NUCLEATING A POLYOLEFIN COMPOSITION WITH ACETAL-BASED COMPOUNDS MILLIKEN & CO (US) 2007-07-04 EP claimed
CN-1984949-A Method for nucleating polyolefin compositions with acetal-based compounds MILLIKEN & CO (US) 2007-06-20 CN claimed
EP-1740653-A2 METHOD OF NUCLEATING A POLYOLEFIN COMPOSITION WITH ACETAL-BASED COMPOUNDS Milliken & Company (US) 2007-01-10 EP claimed
US-7157510-B2 Method of nucleating a polyolefin composition with acetal-based compounds MILLIKEN & COMPANY (US) 2007-01-02 US claimed
WO-2005111134-A2 METHOD OF NUCLEATING A POLYOLEFIN COMPOSITION WITH ACETAL-BASED COMPOUNDS MILLIKEN & COMPANY (US) 2005-11-24 WO claimed
WO-2005108479-A2 ACETAL-BASED COMPOSITIONS MILLIKEN & COMPANY (US) 2005-11-17 WO claimed
US-20050239926-A1 Method of nucleating a polyolefin composition with acetal-based compounds MILLIKEN & COMPANY 2005-10-27 US claimed
US-20050239928-A1 Acetal-based compositions MILLIKEN & COMPANY 2005-10-27 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050239928-A1 Acetal-based compositions PCNA, RAD51, AR ALDH1A1 575/4885LMNA 918/4885TACR2 4807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.