Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.63 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | DPYD | Q12882 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214698 | 0.84 | DHFR (0.63) | DHFRMAOBMPOLTA4HMAPK14 | |
| SCHEMBL28438782 | 0.82 | DHFR (0.63) | DHFRLTA4H | |
| SCHEMBL18586501 | 0.80 | DHFR (0.65) | DHFRMAOBMPODPYDCYP4F2 | |
| SCHEMBL2259723 | 0.79 | LTA4H (0.53) | MAOBLTA4HMAPK14SMN1; SMN2 | |
| SCHEMBL28437377 | 0.79 | BACE1 (0.49) | DHFRMPOLTA4HMAPK14 | |
| SCHEMBL14007501 | 0.76 | BACE1 (0.68) | DHFRMAOBLTA4HMAPK14ALDH1A1 | |
| SCHEMBL9037844 | 0.76 | LTA4H (0.50) | MAOBLTA4HMAPK14SMN1; SMN2 | |
| SCHEMBL510988 | 0.75 | DHFR (0.47) | DHFRMAOBMPOLTA4HMAPK14 | |
| SCHEMBL18586017 | 0.74 | DHFR (0.61) | DHFRMAOBMPOALDH1A1MEN1 | |
| SCHEMBL29442826 | 0.74 | BACE1 (0.50) | DHFRMAOBMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287399-A1 | Substituted Aminopyridines and Uses Thereof | ASTRAZENECA AB (SE) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287399-A1 | Substituted Aminopyridines and Uses Thereof | PSEN2, SLC1A2, PSEN1 | DHFR 905/4885MAOB 244/4885MPO 1943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.