Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.63 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | DPYD | Q12882 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL4934728 | 0.84 | DHFR (0.63) | DHFRMPOMAOBDPYDBCHE | |
| SCHEMBL18586501 | 0.83 | DHFR (0.65) | DHFRMPOMAOBDPYDBCHE | |
| SCHEMBL5212593 | 0.82 | DHFR (0.65) | DHFR | |
| SCHEMBL7499087 | 0.81 | LTA4H (0.43) | MPOLTA4HMAPK14 | |
| SCHEMBL5215414 | 0.77 | DHFR (0.48) | DHFRIGF1R | |
| SCHEMBL7004436 | 0.77 | MAOB (0.59) | MAOB | |
| SCHEMBL5218890 | 0.76 | ROCK1 (0.52) | MPO | |
| SCHEMBL5215267 | 0.75 | ABCB1 (0.47) | MAOBALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL5214956 | 0.74 | CCR5 (0.52) | LTA4HMAPK14ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL18586017 | 0.74 | DHFR (0.61) | DHFRMPOMAOBBCHECYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | claimed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | claimed |