Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 4/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 5/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355279 | 0.91 | CHRNB4 (0.53) | CHRNB4CHRNA3IDO1SLC6A3TRPA1 | |
| SCHEMBL961750 | 0.83 | SLC6A3 (0.53) | CHRNB4CHRNA3IDO1SLC6A3TRPA1 | |
| SCHEMBL961019 | 0.83 | SLC6A3 (0.57) | CHRNB4CHRNA3IDO1SLC6A3TRPA1 | |
| SCHEMBL959762 | 0.81 | SLC6A3 (0.58) | CHRNB4CHRNA3IDO1SLC6A3TRPA1 | |
| SCHEMBL13124077 | 0.81 | SLC6A3 (0.58) | CHRNB4CHRNA3IDO1SLC6A3TRPA1 | |
| SCHEMBL8191324 | 0.79 | CHRNB4 (0.46) | CHRNB4CHRNA3SLC6A3 | |
| Hydrochloric Acid SCHEMBL2586181 | 0.77 | CHRNB4 (0.45) | CHRNB4CHRNA3SLC6A3 | |
| SCHEMBL14415621 | 0.75 | IDO1 (0.48) | CHRNB4CHRNA3IDO1 | |
| SCHEMBL17892330 | 0.74 | SLC6A3 (0.55) | CHRNB4CHRNA3IDO1SLC6A3MEN1 | |
| SCHEMBL8437518 | 0.73 | CHRNB4 (0.49) | CHRNB4CHRNA3TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | CHRNB4 4413/4885CHRNA3 3843/4885IDO1 3425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.