Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 6/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5821397 | 0.76 | GABRG2 (0.64) | GABRG2GABRB3GABRA5 | |
| SCHEMBL3574029 | 0.67 | GABRG2 (1.00) | GABRG2GABRB3GABRA5 | |
| SCHEMBL3871909 | 0.65 | GABRG2 (0.68) | GABRG2GABRB3GABRA5 | |
| SCHEMBL6260912 | 0.58 | KDM4E (1.00) | KDM4EALDH1A1GLAKMT2AMEN1 | |
| SCHEMBL16252551 | 0.56 | SMN1; SMN2 (0.54) | KDM4EALDH1A1KMT2AMEN1CYP2C19 | |
| SCHEMBL24671110 | 0.56 | SMN1; SMN2 (0.57) | KDM4EALDH1A1KMT2AMEN1CYP2C19 | |
| SCHEMBL18880072 | 0.56 | ALDH1A1 (0.73) | KDM4EALDH1A1GLAKMT2AMEN1 | |
| SCHEMBL8737928 | 0.56 | POLB (0.61) | KDM4EALDH1A1GLAKMT2AMEN1 | |
| SCHEMBL16252564 | 0.55 | SMARCA2 (0.58) | KDM4EALDH1A1GLAKMT2AMEN1 | |
| SCHEMBL25900637 | 0.55 | KMT2A (0.53) | KDM4EALDH1A1GLAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008515941-A | — | — | 2008-05-15 | — | — | JP | claimed |
| EP-1809297-A1 | IMIDAZO[1,5A]TRIAZOLO[1,5D]BENZODIAZEPINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-Roche AG (CH) | 2007-07-25 | — | — | EP | claimed |