Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.78 |
| ▸ | APP | P05067 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.61 |
| ▸ | IAPP | P10997 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | BCR | P11274 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | FDPS | P14324 | 1/20 | 0.57 |
| ▸ | ALPI | P09923 | 2/20 | 0.57 |
| ▸ | ALPG | P10696 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935429 | 1.00 | TOP2A (0.78) | TOP2AAPPALDH1A1PTGS1IAPP | |
| SCHEMBL4835689 | 0.88 | TOP2A (0.78) | TOP2AAPPALDH1A1ABCB1ABL1 | |
| Ethyl Curcumin SCHEMBL8965258 | 0.88 | TOP2A (1.00) | TOP2AAPPALDH1A1PTGS1ABCB1 | |
| SCHEMBL4621488 | 0.88 | TOP2A (0.78) | TOP2AAPPALDH1A1ABCB1ABL1 | |
| Ethyl Curcumin SCHEMBL8965263 | 0.88 | TOP2A (1.00) | TOP2AAPPALDH1A1PTGS1ABCB1 | |
| SCHEMBL27720466 | 0.88 | IAPP (0.61) | TOP2AAPPPTGS1IAPPKMT2A | |
| SCHEMBL31380860 | 0.88 | TOP2A (0.78) | TOP2AAPPALDH1A1ABCB1ABL1 | |
| SCHEMBL27211484 | 0.87 | TOP2A (0.86) | TOP2AAPPALDH1A1PTGS1IAPP | |
| SCHEMBL14253556 | 0.85 | MAOB (0.80) | TOP2AAPPALDH1A1ABCB1ABL1 | |
| SCHEMBL7245921 | 0.85 | TOP2A (0.79) | TOP2AAPPALDH1A1PTGS1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1783115-B1 | ARYLAMINE KETONES, THEIR PREPARATION METHODS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | INST MATERIA MEDICA CAMS (CN) | 2016-07-13 | — | — | EP | disclosed |
| US-8524744-B2 | preventing and/or treating the diseases related to the plaque-activating factors, especially in anti-inflammation and immunization, more especially in the treatment of the acute or chronic inflammation, such as, osteoarthritis, oarthritis deformans, etc. | INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2013-09-03 | — | — | US | disclosed |
| US-20080221106-A1 | Arylamine Ketones, Their Preparation Methods, The Pharmaceutical Composition Containing Them And Their Use | INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2008-09-11 | — | — | US | disclosed |
| CN-101146772-A | Arylamine ketone compound, synthesis method thereof, pharmaceutical composition containing arylamine ketone compound and application of arylamine ketone compound | INST MATERIA MEDICA CAMS (CN) | 2008-03-19 | — | — | CN | disclosed |
| EP-1783115-A1 | ARYLAMINE KETONES, THEIR PREPARATION METHODS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2007-05-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221106-A1 | Arylamine Ketones, Their Preparation Methods, The Pharmaceutical Composition Containing Them And Their Use | AHR, KYNU, AADAC | TOP2A 3950/4885APP 245/4885ALDH1A1 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.