Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.41 |
| ▸ | KLK7 | P49862 | 3/20 | 0.41 |
| ▸ | PTGIR | P43119 | 2/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1326645 | 0.88 | CNR1 (0.49) | SMN1; SMN2PTGIRNPC1RAB9A | |
| SCHEMBL492809 | 0.83 | POLB (0.47) | SMN1; SMN2PTGIRGPR88ALDH1A1 | |
| SCHEMBL2308011 | 0.81 | CNR2 (0.50) | SMN1; SMN2UTS2RNPC1RAB9ALMNA | |
| SCHEMBL493552 | 0.81 | TSHR (0.43) | TSHRUTS2RKLK7LMNAALDH1A1 | |
| SCHEMBL28807443 | 0.80 | PTGIR (0.46) | TSHRPTGIRCYP3A4 | |
| SCHEMBL1326835 | 0.78 | P2RX7 (0.52) | NPC1RAB9AALDH1A1 | |
| SCHEMBL2307388 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2PTGIRNPC1RAB9A | |
| SCHEMBL2305686 | 0.78 | PTGIR (0.43) | TSHRPTGIRGPR88ALDH1A1CYP3A4 | |
| SCHEMBL1327847 | 0.78 | POLB (0.47) | SMN1; SMN2PTGIRGPR88LMNAALDH1A1 | |
| SCHEMBL493195 | 0.77 | GAA (0.46) | TSHRSMN1; SMN2PTGIRGPR88NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | TSHR 4051/4885SMN1; SMN2 1729/4885UTS2R 3723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.