Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.62 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 6/20 | 0.61 |
| ▸ | EGFR | P00533 | 11/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | MET | P08581 | 2/20 | 0.55 |
| ▸ | LTK | P29376 | 2/20 | 0.55 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.55 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.55 |
| ▸ | FLT4 | P35916 | 2/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937051 | 0.97 | KDR (0.62) | KDREPHB4EPHA2SRCEGFR | |
| SCHEMBL4931410 | 0.90 | MAPT (0.66) | SRCEGFRPI4KBMAPTMAPK1 | |
| SCHEMBL4938676 | 0.90 | MAPT (0.60) | KDREPHB4EPHA2SRCEGFR | |
| SCHEMBL4759186 | 0.89 | MAPT (0.57) | KDREPHB4EPHA2SRCEGFR | |
| SCHEMBL4791053 | 0.87 | MAPT (0.61) | KDREPHB4EPHA2SRCEGFR | |
| SCHEMBL4758836 | 0.86 | MAPT (0.60) | KDREPHB4EPHA2SRCEGFR | |
| SCHEMBL4937677 | 0.85 | SRC (0.57) | KDREPHB4SRCEGFRPI4KB | |
| SCHEMBL4935871 | 0.84 | RAF1 (0.64) | KDREGFRPI4KBMAPTMAPK1 | |
| SCHEMBL4007243 | 0.83 | CYP1A2 (0.67) | EGFRPI4KBMAPTMAPK1AHR | |
| SCHEMBL4759642 | 0.82 | SRC (0.60) | KDREPHB4SRCEGFRPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080267914-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080267914-A1 | Chemical Compounds | RNASEL, ZC3HAV1L, RNASEH1 | KDR 2135/4885EPHB4 3306/4885EPHA2 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.