Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1769965 | 0.81 | TSHR (0.57) | LMNATSHRTHRB | |
| SCHEMBL28091393 | 0.79 | LMNA (0.50) | LMNATSHRTHRB | |
| SCHEMBL6011520 | 0.78 | — | — | |
| SCHEMBL5465707 | 0.77 | LMNA (0.48) | LMNATSHRTHRB | |
| SCHEMBL202565 | 0.75 | — | — | |
| SCHEMBL27064 | 0.74 | LMNA (0.73) | LMNATHRB | |
| SCHEMBL5391567 | 0.74 | LMNA (0.44) | LMNATSHR | |
| SCHEMBL28003468 | 0.73 | LMNA (0.55) | LMNATSHRTHRB | |
| SCHEMBL18194367 | 0.73 | LMNA (0.48) | LMNAMAPK1THRB | |
| SCHEMBL5388587 | 0.72 | LMNA (0.42) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070916-A1 | Dihydropyrancarboxamides and uses thereof | SCHREIBER STUART L | 2008-03-20 | — | — | US | disclosed |
| US-7186709-B2 | Subjecting a vinyl ethers and an unsaturated ketoester to suitable conditions to generate a scaffold having the core dihydropyrancarboxamide or dihydropyrancarboxylic ester or acid; anticarcinogenic agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-03-06 | — | — | US | disclosed |
| US-20040059138-A1 | Dihydropyrancarboxamides and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040059138-A1 | Dihydropyrancarboxamides and uses thereof | CCNA1, DPYD, DHFR | LMNA 3785/4885TSHR 4030/4885ALDH1A1 71/4885 |
| US-20080070916-A1 | Dihydropyrancarboxamides and uses thereof | CCNA1, DPYD, DHFR | LMNA 3385/4885TSHR 3906/4885ALDH1A1 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.