Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27787878 | 0.92 | EPAS1 (0.53) | EPAS1MAPK1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL5384243 | 0.85 | L3MBTL1 (0.61) | EPAS1MAPK1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL30615510 | 0.85 | EPAS1 (0.56) | EPAS1MAPK1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL4940492 | 0.85 | EPAS1 (0.56) | EPAS1MAPK1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL9362373 | 0.84 | MAPT (0.61) | EPAS1MAPK1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL2676946 | 0.82 | MAPK1 (0.64) | EPAS1MAPK1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL30615696 | 0.82 | MAPT (0.64) | EPAS1MAPK1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL4945081 | 0.82 | MAPT (0.64) | EPAS1MAPK1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL4064354 | 0.82 | EPAS1 (0.59) | EPAS1MAPK1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL21187572 | 0.81 | EPAS1 (0.53) | EPAS1MAPK1ALDH1A1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161366-A1 | AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161366-A1 | AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | SLC6A4, SLC6A2, SLC6A3 | EPAS1 1073/4885MAPK1 1634/4885ALDH1A1 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.