Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.61 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11492017 | 0.87 | TSHR (0.62) | L3MBTL1MAPK1TSHRALDH1A1TDP1 | |
| SCHEMBL9362373 | 0.86 | MAPT (0.61) | L3MBTL1EPAS1MAPK1ALDH1A1TDP1 | |
| SCHEMBL2676946 | 0.85 | MAPK1 (0.64) | L3MBTL1EPAS1MAPK1ALDH1A1TDP1 | |
| SCHEMBL4939342 | 0.85 | EPAS1 (0.60) | L3MBTL1EPAS1MAPK1ALDH1A1TDP1 | |
| SCHEMBL8884629 | 0.84 | MAPK1 (0.56) | L3MBTL1EPAS1MAPK1TSHRALDH1A1 | |
| SCHEMBL4588213 | 0.82 | L3MBTL1 (0.55) | L3MBTL1EPAS1MAPK1ALDH1A1TDP1 | |
| SCHEMBL397773 | 0.81 | MAPK1 (0.77) | L3MBTL1EPAS1MAPK1ALDH1A1TDP1 | |
| Nitric Acid SCHEMBL11144683 | 0.80 | TSHR (0.50) | L3MBTL1MAPK1TSHRALDH1A1TDP1 | |
| SCHEMBL27498162 | 0.79 | VCAM1 (0.63) | L3MBTL1MAPK1ALDH1A1TDP1CASP7 | |
| SCHEMBL247794 | 0.79 | L3MBTL1 (0.74) | L3MBTL1EPAS1MAPK1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244746-B2 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244746-B2 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244746-B2 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |
| US-7238699-B2 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238699-B2 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238699-B2 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-03 | — | — | US | disclosed |
| US-7211669-B2 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-01 | — | — | US | disclosed |
| US-7211669-B2 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-01 | — | — | US | disclosed |
| US-7211669-B2 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-01 | — | — | US | disclosed |
| US-7125990-B2 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-10-24 | — | — | US | disclosed |
| US-20040225130-A1 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-11 | — | — | US | disclosed |
| EP-1359916-A4 | IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-04-07 | — | — | EP | disclosed |
| EP-1359916-A1 | IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS | Bristol-Myers Squibb Company (US) | 2003-11-12 | — | — | EP | disclosed |
| US-20020183375-A1 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2002-12-05 | — | — | US | disclosed |
| WO-2002058704-A1 | IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |
| US-4853400-A | IMIDAZOLE OR TRIAZOLE SUBSTITUTED INDAZOLE; | SCHERING AGROCHEMICALS LIMITED (GB) | 1989-08-01 | — | — | US | disclosed |
| US-4772613-A | Fungicides | SCHERING AGROCHEMICALS LTD. (GB) | 1988-09-20 | — | — | US | disclosed |
| EP-0247760-A2 | Benzoheterocyclic fungicides | SCHERING AGROCHEMICALS LIMITED (GB) | 1987-12-02 | — | — | EP | disclosed |
| US-4510141-A | (1,2,4) TRIAZOLO(1,5-A) QUINOXALINE OR PYRIDO(2,3-E)(U,2,4)TRIAZOLO(1,5-A)PYRAZINE COMPOUNDS | CIBA-GEIGY CORPORATION (US) | 1985-04-09 | — | — | US | disclosed |
| EP-0074929-A1 | Polycyclic polyazaheterocycles, process for their preparation and pharmaceutical preparations containing them | CIBA-GEIGY AG (CH) | 1983-03-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040225130-A1 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | CRH, CRHR1, CRHR2 | L3MBTL1 4510/4885EPAS1 2143/4885MAPK1 191/4885 |
| US-20020183375-A1 | Imidazolyl derivatives as corticotropin releasing factor inhibitors | CRH, CRHR1, CRHR2 | L3MBTL1 4510/4885EPAS1 2143/4885MAPK1 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.