Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14008410 | 0.98 | ALDH1A1 (0.69) | ALDH1A1RAB9ALMNANPC1KDM4E | |
| Bromide SCHEMBL3849524 | 0.84 | ALDH1A1 (0.72) | ALDH1A1RAB9AKDM4EMAPTPABPC1 | |
| Bromide SCHEMBL3847335 | 0.84 | ALDH1A1 (0.72) | ALDH1A1RAB9ANPC1KDM4EMAPT | |
| Bromide SCHEMBL2947796 | 0.84 | ALDH1A1 (0.72) | ALDH1A1LMNAKDM4EMAPTPABPC1 | |
| Bromide SCHEMBL122633 | 0.84 | ALDH1A1 (1.00) | ALDH1A1RAB9ALMNAKDM4EMAPT | |
| Bromide SCHEMBL7402288 | 0.84 | ALDH1A1 (1.00) | ALDH1A1RAB9ALMNAKDM4EMAPT | |
| SCHEMBL6935140 | 0.83 | ALDH1A1 (0.69) | ALDH1A1KDM4EMAPTPABPC1KMT2A | |
| SCHEMBL7074123 | 0.83 | ALDH1A1 (0.69) | ALDH1A1RAB9ANPC1KDM4EMAPT | |
| SCHEMBL6936032 | 0.83 | ALDH1A1 (0.69) | ALDH1A1RAB9ANPC1KDM4EMAPT | |
| Bromide SCHEMBL7402285 | 0.83 | ALDH1A1 (0.97) | ALDH1A1RAB9ALMNAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293931-A1 | Methods and compositions for the removal of nucleic acid amplification inhibitors | LOS ALAMOS NATIONAL SECURITY, LLC | 2008-11-27 | — | — | US | disclosed |
| US-20070065841-A1 | Methods and compositions for the removal of nucleic acid amplification inhibitors | ENERGY, U.S. DEPARTMENT OF | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293931-A1 | Methods and compositions for the removal of nucleic acid amplification inhibitors | POLRMT, FBL, POLL | ALDH1A1 2004/4885RAB9A 4811/4885LMNA 548/4885 |
| US-20070065841-A1 | Methods and compositions for the removal of nucleic acid amplification inhibitors | POLRMT, FBL, POLL | ALDH1A1 2004/4885RAB9A 4811/4885LMNA 548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.