Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | GRN | P28799 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL134693 | 0.81 | ERCC5 (0.56) | KCNH2RAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL29403016 | 0.81 | ERCC5 (0.56) | KCNH2RAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL16863058 | 0.80 | HCAR2 (0.55) | KCNH2MAPTMEN1KMT2A | |
| SCHEMBL138022 | 0.79 | GSK3B (0.57) | KCNH2RAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL1989864 | 0.75 | CES2 (0.54) | KCNH2ALDH1A1HCAR1MCL1CYP1A2 | |
| SCHEMBL25992463 | 0.75 | GSK3B (0.44) | KCNH2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL4850442 | 0.75 | TPMT (0.46) | TPMTKCNH2MAPTALDH1A1MEN1 | |
| SCHEMBL395103 | 0.75 | GSK3B (0.48) | KCNH2RAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL30712974 | 0.75 | TSHR (0.52) | ALDH1A1KDM4E | |
| SCHEMBL133027 | 0.75 | TSHR (0.52) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119192171-A | Small molecule compounds and their use in vitro expansion of hematopoietic stem cells and/or progenitor cells | 上海交通大学医学院 | 2024-12-27 | — | — | CN | disclosed |
| EP-2291358-B1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | MERCK SHARP & DOHME (US) | 2018-03-28 | — | — | EP | disclosed |
| US-8623818-B2 | Glucagon receptor antagonists, compositions, and methods for their use | MERCK SHARP & DOHME CORP. (US) | 2014-01-07 | — | — | US | disclosed |
| US-20110065634-A1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | MERCK SHARP & DOHME LLC | 2011-03-17 | — | — | US | disclosed |
| US-20110065634-A1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | MERCK SHARP & DOHME LLC | 2011-03-17 | — | — | US | disclosed |
| US-20080167322-A1 | Substituted Pyrazoles as Modulators of Chemokine Receptors | MERCK SHARP & DOHME CORP. | 2008-07-10 | — | — | US | disclosed |
| EP-1853260-A1 | SUBSTITUTED PYRAZOLES AS MODULATORS OF CHEMOKINE RECEPTORS | Merck & Co., Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006088813-A1 | SUBSTITUTED PYRAZOLES AS MODULATORS OF CHEMOKINE RECEPTORS | MERCK & CO., INC. (US) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167322-A1 | Substituted Pyrazoles as Modulators of Chemokine Receptors | CCR1, CCR3, CCR2 | TPMT 3160/4885KCNH2 3819/4885RAB9A 1325/4885 |
| US-20110065634-A1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | GLP1R, GCGR, GIPR | TPMT 4658/4885KCNH2 1130/4885RAB9A 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.