Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | CES2 | O00748 | 3/20 | 0.54 |
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28841615 | 0.89 | MAPT (0.62) | GSK3BCES2CES1L3MBTL1NPC1 | |
| SCHEMBL395103 | 0.89 | GSK3B (0.48) | GSK3BCES1L3MBTL1NPC1ALDH1A1 | |
| SCHEMBL28581878 | 0.81 | GSK3B (0.59) | GSK3BCES2CES1L3MBTL1NPC1 | |
| SCHEMBL11770219 | 0.81 | CYP19A1 (0.57) | CES2L3MBTL1NPC1ALDH1A1MAPT | |
| SCHEMBL14918493 | 0.81 | TSHR (0.52) | GSK3BCES2CES1ALDH1A1ALOX15 | |
| SCHEMBL10489592 | 0.80 | NPC1 (0.57) | GSK3BCES2CES1L3MBTL1NPC1 | |
| SCHEMBL8610853 | 0.79 | CYP19A1 (0.51) | GSK3BNPC1MAPTRAB9ATSHR | |
| SCHEMBL3659298 | 0.79 | TPMT (0.46) | GSK3BMAPTKCNH2KDM4ECA1 | |
| SCHEMBL135383 | 0.79 | GSK3B (0.55) | GSK3BCES2CES1L3MBTL1NPC1 | |
| SCHEMBL1568921 | 0.79 | GSK3B (0.57) | GSK3BCES2CES1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 494 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115974721-B | Method for synthesizing 2-carbonyl substituted nitrile compound through 2, 2-trifluoroethyl ketone | 平顶山学院 | 2024-07-02 | — | — | CN | claimed |
| CN-115974721-A | Method for synthesizing 2-carbonyl substituted nitrile compound through 2,2,2-trifluoroethyl ketone | 平顶山学院 | 2023-04-18 | — | — | CN | claimed |
| EP-3555059-A1 | PROCESS FOR THE MANUFACTURE OF DIAZEPINE DERIVATIVES | H. Hoffnabb-La Roche Ag (CH) | 2019-10-23 | — | — | EP | claimed |
| US-20190284202-A1 | PROCESS FOR THE MANUFACTURE OF DIAZEPINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2019-09-19 | — | — | US | claimed |
| WO-2018109053-A1 | PROCESS FOR THE MANUFACTURE OF DIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-06-21 | — | — | WO | claimed |
| CN-106432230-A | Pyridino-pyrazolon derivative and application thereof medicine against anti-influenza-a virus | 南方医科大学 | 2017-02-22 | — | — | CN | claimed |
| CN-103739588-B | Simple synthesis method of 2-aminothiophene derivative | XINFA PHARMACEUTICAL CO LTD | 2015-07-01 | — | — | CN | claimed |
| EP-4743459-A1 | BICYCLIC AND MONOCYCLIC TRPA1 INHIBITORS | D.E. Shaw Research, LLC (US) | 2026-05-20 | — | — | EP | disclosed |
| US-12612400-B2 | Pyrrolopyridine derivative preparation method | ST PHARM CO., LTD. (KR) | 2026-04-28 | — | — | US | disclosed |
| EP-4276101-B1 | PYRROLOPYRIDINE DERIVATIVE PREPARATION METHOD | ST PHARM CO LTD (KR) | 2026-03-04 | — | — | EP | disclosed |
| EP-4658262-A1 | BICYCLIC IMIDE COMPOUNDS AS TRPA1 INHIBITORS | D.E. Shaw Research, LLC (US) | 2025-12-10 | — | — | EP | disclosed |
| US-20250270198-A1 | PYRIDONE COMPOUNDS AS TRPA1 INHIBITORS | D. E. SHAW RESEARCH, LLC | 2025-08-28 | — | — | US | disclosed |
| US-20250154139-A1 | PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS | D. E. SHAW RESEARCH, LLC | 2025-05-15 | — | — | US | disclosed |
| EP-0016277-B1 | 2-CARBONYL-3-HYDROXY-ALKENONITRILES, THEIR USE AS ANTI-ARTHRITIC AGENTS AND PROCESSES FOR THEIR PREPARATION | AMERICAN CYANAMID COMPANY (US) | 1981-12-02 | — | — | EP | disclosed |
| US-4259256-A | ANTIINFLAMMATORY | AMERICAN CYANAMID COMPANY (US) | 1981-03-31 | — | — | US | disclosed |
| EP-0016277-A1 | 2-Carbonyl-3-hydroxy-alkenonitriles, their use as anti-arthritic agents and processes for their preparation | AMERICAN CYANAMID COMPANY (US) | 1980-10-01 | — | — | EP | disclosed |
| WO-1980000964-A1 | ANTI-INFLAMMATORY AGENTS INCLUDING 2-CARBONYL-3-HYDROXY-2-ALKENONITRILES | AMERICAN CYANAMID CO (US) | 1980-05-15 | — | — | WO | disclosed |
| US-4181677-A | ANTIINFLAMMATORY AGENTS | AMERICAN CYANAMID COMPANY (US) | 1980-01-01 | — | — | US | disclosed |
| US-4173650-A | ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1979-11-06 | — | — | US | disclosed |
| US-4088673-A | Process for the preparation of styryl dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1978-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284202-A1 | PROCESS FOR THE MANUFACTURE OF DIAZEPINE DERIVATIVES | DRD5, GABRA5, GABRA4 | GSK3B 524/4885CES2 575/4885CES1 1575/4885 |
| US-20250154139-A1 | PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS | TRPA1, TRPV1, TRPV5 | GSK3B 3754/4885CES2 1988/4885CES1 2806/4885 |
| US-12612400-B2 | Pyrrolopyridine derivative preparation method | PNP, MAP2K4, MAP2K5 | GSK3B 922/4885CES2 599/4885CES1 92/4885 |
| US-20250270198-A1 | PYRIDONE COMPOUNDS AS TRPA1 INHIBITORS | TRPA1, TRPV1, TRPV6 | GSK3B 3115/4885CES2 4450/4885CES1 2524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.