Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Edetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | EYA2 | O00167 | 1/20 | 0.64 |
| ▸ | APP | P05067 | 1/20 | 0.64 |
| ▸ | ACE | P12821 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edetic Acid SCHEMBL9048495 | 0.94 | TDP1 (0.56) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL5470836 | 0.94 | TDP1 (0.56) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL7899129 | 0.94 | TDP1 (0.56) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL1668331 | 0.94 | TDP1 (0.56) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL9225789 | 0.92 | TDP1 (0.54) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL9176717 | 0.90 | TDP1 (0.52) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL11797803 | 0.89 | TDP1 (0.50) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL11234714 | 0.87 | KDM4E (0.52) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL11234740 | 0.87 | KDM4E (0.52) | TDP1EYA2APPACELMNA | |
| Bicine SCHEMBL2555717 | 0.87 | LMNA (0.50) | TDP1EYA2APPACELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3334 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753635-B2 | Methods and systems and related compositions for mixtures separation with a solid matrix | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2023-09-12 | — | — | US | claimed |
| US-20230175035-A1 | METHOD FOR THE RAPID DETECTION OF BACTERIAL SPORES IN AN INDUSTRIAL PROCESS | ECOLAB USA INC. (US) | 2023-06-08 | — | — | US | claimed |
| WO-2023021230-A1 | SILICA PARTICLES FOR ENCAPSULATING NUCLEIC ACIDS | FUNDACIÓN INSTITUTO DE INVESTIGACIÓN MARQUÉS DE VALDECILLA (ES) | 2023-02-23 | — | — | WO | claimed |
| US-20220403459-A1 | IMPROVEMENTS IN OR RELATING TO NICKING ENZYMES | LUMIRADX UK LTD. (GB) | 2022-12-22 | — | — | US | claimed |
| CN-114651058-A | Systems and methods for sample preparation, data generation, and protein corona analysis | 禧尔公司 | 2022-06-21 | — | — | CN | claimed |
| EP-4010456-A1 | SYSTEMS AND METHODS FOR SAMPLE PREPARATION, DATA GENERATION, AND PROTEIN CORONA ANALYSIS | Seer, Inc. (US) | 2022-06-15 | — | — | EP | claimed |
| EP-3987018-A1 | IMPROVEMENTS IN OR RELATING TO NICKING ENZYMES | LUMIRADX UK LTD (GB) | 2022-04-27 | — | — | EP | claimed |
| US-20220049242-A1 | METHODS AND SYSTEMS AND RELATED COMPOSITIONS FOR MIXTURES SEPARATION WITH A SOLID MATRIX | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2022-02-17 | — | — | US | claimed |
| CN-113993995-A | Improvements in or relating to nicking enzymes | 卢米拉特英国有限公司 | 2022-01-28 | — | — | CN | claimed |
| WO-2021231607-A1 | POINT OF NEED DIAGNOSTIC DEVICE AND METHODS OF USE THEREOF | GODX, INC. (US) | 2021-11-18 | — | — | WO | claimed |
| US-8217024-B2 | Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof | TEVA WOMEN'S HEALTH, INC. (US) | 2012-07-10 | — | — | US | claimed |
| US-20110275090-A1 | USE OF ACHROMOPEPTIDASE FOR LYSIS AT ROOM TEMPERATURE | BECTON, DICKINSON AND COMPANY (US) | 2011-11-10 | — | — | US | claimed |
| WO-2011115975-A2 | USE OF ACHROMOPEPTIDASE FOR LYSIS AT ROOM TEMPERATURE | BECTON, DICKINSON AND COMPANY (US) | 2011-09-22 | — | — | WO | claimed |
| CN-101831489-A | Method for detecting desoxyribonucleic acid anti-counterfeiting maker by utilizing loop-mediated isothermal amplification technology | SUN XINGJIANG | 2010-09-15 | — | — | CN | claimed |
| US-7459548-B2 | Kits and processes for removing contaminants from nucleic acids in environmental and biological samples | MO BIO LABORATORIES, INC. (US) | 2008-12-02 | — | — | US | claimed |
| US-20070191321-A1 | Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof | TEVA WOMEN'S HEALTH, INC. | 2007-08-16 | — | — | US | claimed |
| US-6806399-B1 | COMPRISES MIXING SILICON CARBIDE FIBERS SOLOUTION WITH POLLEN GERMINATION MEDIUM AND DNA, ADDING FRESH POLLEN TO FORM PASTE, VORTEXING AND APPLYING TO LEAVES; FOR HIGH EFFICIENCY AND REPRODUCIBILITY; HERBICIDE/ANTIBIOTIC RESISTANCE | CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. (IL) | 2004-10-19 | — | — | US | claimed |
| US-6110745-A | CONTACTING NUCLEIC ACID WITH SOLUTION OF NON-CATIONIC AND CATIONIC LIPIDS, REMOVING AQUEOUS PORTION, REMOVING ORGANIC SOLVENT PORTION TO FORM COMPLEX IN THE FORM OF A FILM, AND HYDRATING COMPLEX TO FORM PARTICLE | INEX PHARMACEUTICALS CORP. (CA) | 2000-08-29 | — | — | US | claimed |
| US-6080384-A | Methods for radionuclide-labeling of biomolecules and kits utilizing the same | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 2000-06-27 | — | — | US | claimed |
| WO-1999005303-A1 | PREPARATION OF LIPID-NUCLEIC ACID PARTICLES USING A SOLVENT EXTRACTION AND DIRECT HYDRATION METHOD | INEX PHARMACEUTICALS CORPORATION (CA) | 1999-02-04 | — | — | WO | claimed |