Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 5/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4953693 | 0.88 | GRIA4 (0.49) | ACLYRXRARXRBRXRGGRIA4 | |
| SCHEMBL4953413 | 0.85 | PTGS2 (0.48) | ACLYADAMTS4GRIA4 | |
| SCHEMBL4950027 | 0.84 | TDP1 (0.39) | ACLYGRIA4 | |
| SCHEMBL4950640 | 0.83 | KDM4E (0.43) | ACLYGAAPOLBGRIA4 | |
| SCHEMBL4950128 | 0.82 | GRIA2 (0.52) | MEN1KMT2AGRIA2KCNH2ADAMTS4 | |
| SCHEMBL4950718 | 0.82 | RARB (0.41) | GAAGRIA4 | |
| SCHEMBL27724208 | 0.81 | ACLY (0.42) | ACLY | |
| SCHEMBL27703688 | 0.81 | TTR (0.41) | ACLYPOLBMEN1KMT2AGRIA4 | |
| SCHEMBL4945608 | 0.81 | TDP1 (0.43) | ACLYPOLBMEN1KMT2A | |
| SCHEMBL4950817 | 0.81 | PTGES2 (0.42) | ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893597-B1 | AMPA RECEPTOR POTENTIATORS | LILLY CO ELI (US) | 2008-11-12 | — | — | EP | disclosed |