SCHEMBL4947340

SCHEMBL4947340

Clc1csc(-c2ccccc2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 2/20 0.50
AR P10275 1/20 0.47
HSD17B1 P14061 4/20 0.42
HSD17B2 P37059 4/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
DYRK1A Q13627 1/20 0.38
DYRK1B Q9Y463 1/20 0.38
BRD4 O60885 1/20 0.38
TSHR P16473 2/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
TP53 P04637 1/20 0.37
NFKB1 P19838 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37
CFTR P13569 1/20 0.36
MEN1 O00255 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2774954 0.84 CNR1 (0.44) CNR1HSD17B1HSD17B2CYP1A2CYP3A4
SCHEMBL27877828 0.82 HSD17B1 (0.46) CNR1HSD17B1HSD17B2SMN1; SMN2RELA
SCHEMBL11338374 0.78 HSD17B1 (0.55) HSD17B1HSD17B2CYP3A4CYP2C9MEN1
SCHEMBL3927813 0.78 DYRK1A (0.68) CYP1A2CYP3A4CYP2C9DYRK1ADYRK1B
SCHEMBL28574792 0.78 HSD17B1 (0.51) CNR1HSD17B1HSD17B2CYP1A2CYP3A4
SCHEMBL7915311 0.76 HSD17B1 (0.61) CNR1ARHSD17B1HSD17B2CYP3A4
SCHEMBL27662659 0.75 MAOA (0.46) ARTSHRALDH1A1LMNAGAA
SCHEMBL3907230 0.74 AR (0.44) CNR1ARHSD17B1HSD17B2CYP3A4
SCHEMBL14985526 0.74 RAB9A (0.57) NPC1RAB9AMEN1HPGDKMT2A
SCHEMBL17570199 0.73 HSD17B1 (0.62) CNR1ARHSD17B1HSD17B2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017121308-A1 FUSED PYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE Chongqing Fochon Pharmaceutical Co., Ltd. (CN) 2017-07-20 WO disclosed
CN-101273047-A Thieno [2, 3-B ] pyridine-5-carbonitriles as protein kinase inhibitors WYETH CORP (US) 2008-09-24 CN disclosed
EP-1937690-A1 THIENO[2,3-B]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS Wyeth a Corporation of the State of Delaware (US) 2008-07-02 EP disclosed
WO-2007038519-A1 THIENO[2,3-B]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS WYETH (US) 2007-04-05 WO disclosed
EP-1606255-A4 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2007-02-07 EP disclosed
EP-1606255-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2005-12-21 EP disclosed
WO-2004071460-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2004-08-26 WO disclosed
WO-1999043682-A9 2-(HET-)ARYL-4-(CYCLIC AMINO SUBSTITUTED) HETEROARYL FUSED PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS (ANT-)AGONISTS FOR GABA (A) BRAIN RECEPTORS NEUROGEN CORP (US) 1999-11-11 WO disclosed
WO-1999043681-A1 4-(4-PIPERIDYLMETHYLAMINO) SUBSTITUTED HETEROARYL FUSED PYRIDINES: GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1999-09-02 WO disclosed
WO-1999043682-A1 2-(HET-)ARYL-4-(CYCLIC AMINO SUBSTITUTED) HETEROARYL FUSED PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS (ANT-)AGONISTS FOR GABA (A) BRAIN RECEPTORS NEUROGEN CORPORATION (US) 1999-09-02 WO disclosed
EP-0254611-B1 DERIVATIVES OF 8-PHENYLTHIOTETRAHYDROQUINOLINES AND THEIR SALTS, THEIR SYNTHESIS FOR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1991-06-12 EP disclosed
EP-0254611-A1 Derivatives of 8-phenylthiotetrahydroquinolines and their salts, their synthesis for use as medicaments and compositions containing them ROUSSEL-UCLAF (FR) 1988-01-27 EP disclosed