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Tyrosine

Tyrosine

SCHEMBL4948058

NC(=O)C[C@H](N)C(=O)OC[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)OC(=O)[C@@H](N)CC(N)=O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ ITGA4 P13612 4/20 0.32
▸ TYR P14679 1/20 0.32
▸ SLC7A5 Q01650 1/20 0.32
▸ HTR2C P28335 1/20 0.31
▸ HTR2B P41595 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL6157195 0.99 TYR (0.33) ITGA4TYRSLC7A5HTR2CHTR2B
Tyrosine SCHEMBL7630915 0.88 SLC7A5 (0.39) ITGA4SLC7A5
Tyrosine SCHEMBL4948067 0.88 SLC7A5 (0.35) ITGA4SLC7A5
Tyrosine SCHEMBL6157198 0.88 SLC7A5 (0.35) ITGA4SLC7A5
Tyrosine SCHEMBL4947368 0.86 SLC7A5 (0.39) TYRSLC7A5
Tyrosine SCHEMBL6554731 0.84 SLC7A5 (0.36) ITGA4SLC7A5
Tyrosine SCHEMBL6511987 0.84 SLC7A5 (0.36) ITGA4SLC7A5
Dl-Phenylalanine SCHEMBL29201498 0.83 ALPI (0.41) ITGA4SLC7A5HTR2CHTR2B
Proline SCHEMBL7630910 0.82 ITGB3 (0.31) SLC7A5
Tyrosine SCHEMBL6554735 0.82 SLC7A5 (0.39) ITGA4SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1769066-A4 MODIFIED ANTIGEN-PRESENTING CELLS DANA FARBER CANCER INST INC (US) 2008-08-13 — — EP disclosed
EP-1769066-A2 MODIFIED ANTIGEN-PRESENTING CELLS DANA-FARBER CANCER INSTITUTE (US) 2007-04-04 — — EP disclosed
WO-2005113589-A2 MODIFIED ANTIGEN-PRESENTING CELLS DANA-FARBER CANCER INSTITUTE (US) 2005-12-01 — — WO disclosed
EP-1458241-A4 MODIFIED ANTIGEN-PRESENTING CELLS DANA FARBER CANCER INST INC (US) 2005-11-09 — — EP disclosed
US-20050003484-A1 Modified antigen-presenting cells DANA FARBER CANCER INSTITUTE 2005-01-06 — — US disclosed
EP-1458241-A2 MODIFIED ANTIGEN-PRESENTING CELLS DANA-FARBER CANCER INSTITUTE (US) 2004-09-22 — — EP disclosed
WO-2003065977-A9 MODIFIED ANTIGEN-PRESENTING CELLS DANA FARBER CANCER INST INC (US) 2003-10-16 — — WO disclosed
WO-2003065977-A2 MODIFIED ANTIGEN-PRESENTING CELLS DANA-FARBER CANCER INSTITUTE (US) 2003-08-14 — — WO disclosed