Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.47 |
| ▸ | HNF4A | P41235 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL509518 | 0.84 | PTGS2 (0.44) | PTGS2AKR1C3AKR1C2SMN1; SMN2L3MBTL1 | |
| SCHEMBL508994 | 0.81 | PPARG (0.44) | DHFRMCL1EGFRKDM4EAKR1C3 | |
| SCHEMBL6773227 | 0.80 | TSHR (0.57) | KDM4EPTGS2AKR1C3AKR1C2HPGD | |
| SCHEMBL30483161 | 0.80 | TSHR (0.57) | KDM4EPTGS2AKR1C3AKR1C2HPGD | |
| SCHEMBL4071095 | 0.80 | TSHR (0.57) | KDM4EPTGS2AKR1C3AKR1C2HPGD | |
| SCHEMBL509613 | 0.80 | FFAR1 (0.40) | PTGS2AKR1C3AKR1C2SMN1; SMN2L3MBTL1 | |
| SCHEMBL27332946 | 0.79 | PTGS2 (0.58) | ACMSDHNF4AALOX5DHFRMCL1 | |
| SCHEMBL11839204 | 0.77 | ACMSD (0.53) | ACMSDHNF4AALOX5DHFRMCL1 | |
| SCHEMBL6472538 | 0.77 | AKR1C3 (0.49) | AKR1C3AKR1C2RXRARXRB | |
| Xenbucin SCHEMBL24134 | 0.76 | PTGS2 (0.58) | PTGS2AKR1C3AKR1C2SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578910-A4 | NITRILASES | VERENIUM CORP (US) | 2008-06-04 | — | — | EP | disclosed |
| EP-1578910-A2 | NITRILASES | DIVERSA CORPORATION (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2003000840-A2 | NITRILASES | DIVERSA CORPORATION (US) | 2003-01-03 | — | — | WO | disclosed |