Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748903 | 0.84 | MAPK1 (0.54) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL14575084 | 0.76 | ATAD2 (0.44) | HSD17B3PDK1PDK2PDK3PDK4 | |
| SCHEMBL14321151 | 0.69 | PDK1 (0.39) | HSD17B3SRD5A1PDK1PDK2PDK3 | |
| SCHEMBL22835563 | 0.69 | LMNA (0.37) | — | |
| SCHEMBL9891750 | 0.68 | NOTUM (0.50) | NOTUMSRD5A1KMT2A | |
| SCHEMBL2928011 | 0.68 | HTR2C (0.51) | NOTUMHSD17B3SRD5A1DRD2DRD4 | |
| SCHEMBL3971068 | 0.67 | NOTUM (0.73) | NOTUMHSD17B3DRD2DRD4HTR2C | |
| SCHEMBL14321528 | 0.67 | SRD5A1 (0.36) | SRD5A1ALDH1A1 | |
| SCHEMBL1650576 | 0.66 | PDK1 (0.62) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL15103365 | 0.66 | OXTR (0.41) | SRD5A1DRD4ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318999-A1 | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318999-A1 | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators | GRM2, GRM1, GRIN2B | NOTUM 3896/4885HSD17B3 2497/4885SRD5A1 2587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.