Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015695 | 0.84 | KDM4E (0.51) | KDM4EL3MBTL1MAPTNPSR1ALDH1A1 | |
| SCHEMBL2556550 | 0.81 | L3MBTL1 (0.59) | KDM4EL3MBTL1MAPTNPSR1ALDH1A1 | |
| SCHEMBL249539 | 0.81 | ALDH1A1 (0.54) | KDM4EL3MBTL1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL29957820 | 0.81 | ALDH1A1 (0.54) | KDM4EL3MBTL1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL27655777 | 0.81 | L3MBTL1 (0.58) | KDM4EL3MBTL1MAPTNPSR1HPGD | |
| SCHEMBL14162488 | 0.79 | CYP19A1 (0.42) | KDM4EL3MBTL1ALDH1A1PTPN1ADRB2 | |
| SCHEMBL22382257 | 0.79 | ABCB1 (0.51) | ABCB1HTR1A | |
| SCHEMBL4010761 | 0.79 | L3MBTL1 (0.51) | KDM4EL3MBTL1MAPTNPSR1ALDH1A1 | |
| SCHEMBL4706175 | 0.77 | L3MBTL1 (0.50) | KDM4EL3MBTL1MAPTNPSR1ALDH1A1 | |
| SCHEMBL4012576 | 0.77 | ADRB2 (0.46) | KDM4EMAPTALDH1A1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879886-A1 | MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1809280-A2 | MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006119146-A1 | MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2006-11-09 | — | — | WO | disclosed |
| WO-2006044825-A2 | MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2006-04-27 | — | — | WO | disclosed |