Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | STAT1 | P42224 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NQO1 | P15559 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4958360 | 0.89 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL22733326 | 0.82 | KDM4E (0.77) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL27725308 | 0.81 | HSD17B3 (0.69) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL180111 | 0.81 | HPGD (0.50) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL29814668 | 0.81 | HPGD (0.50) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL7115914 | 0.80 | HSD17B3 (0.46) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL38652222 | 0.80 | NQO1 (0.69) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL11748869 | 0.78 | CA1 (0.61) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL4956069 | 0.78 | CCR4 (0.49) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL9636407 | 0.77 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040009911-A1 | Hepsin substrates and prodrugs | IRM, LLC (BM) | 2004-01-15 | — | — | US | claimed |
| WO-2003064620-A2 | HEPSIN SUBSTRATES AND PRODRUGS | IRM, LLC (BM) | 2003-08-07 | — | — | WO | claimed |
| WO-2003029823-A1 | COMBINATORIAL PROTEASE SUBSTRATE LIBRARIES | IRM LLC (BM) | 2003-04-10 | — | — | WO | claimed |
| US-20080032917-A1 | FLAVIVIRUS PROTEASE SUBSTRATES AND INHIBITORS | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2008-02-07 | — | — | US | disclosed |
| WO-2006014232-A2 | DENGUE PROTEASE SUBSTRATES AND INHIBITORS | IRM LLC (BM) | 2006-02-09 | — | — | WO | disclosed |
| US-20050222383-A1 | Prostasin substrates and inhibitors | IRM LLC (BM) | 2005-10-06 | — | — | US | disclosed |
| WO-2005076886-A2 | PROSTASIN SUBSTRATES AND INHIBITORS | IRM LLC (BM) | 2005-08-25 | — | — | WO | disclosed |
| US-20040009911-A1 | Hepsin substrates and prodrugs | IRM, LLC (BM) | 2004-01-15 | — | — | US | disclosed |
| WO-2003064620-A2 | HEPSIN SUBSTRATES AND PRODRUGS | IRM, LLC (BM) | 2003-08-07 | — | — | WO | disclosed |
| WO-2003029823-A1 | COMBINATORIAL PROTEASE SUBSTRATE LIBRARIES | IRM LLC (BM) | 2003-04-10 | — | — | WO | disclosed |
| US-20030059847-A1 | Combinatorial protease substrate libraries | IRM, LLC (BM) | 2003-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009911-A1 | Hepsin substrates and prodrugs | HPN, SPR, TMPRSS15 | KDM4E 4130/4885ALDH1A1 2407/4885HPGD 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.